抗生素对人体微生物群的影响及对宿主健康的影响.pdfVIP

Received: 30 September 2021 | Accepted: 10 December 2021 DOI: 10.1002/mbo3.1260 R E V I E W Impact of antibiotics on the human microbiome and consequences for host health Dhrati V. Patangia1,2,3 | Cornelius Anthony Ryan1 | Eugene Dempsey1 | Reynolds Paul Ross1,3 | Catherine Stanton2,3 1School of Microbiology, University College Cork, Cork, Ireland Abstract 2Teagasc Food Research Centre, Moorepark, It is well established that the gut microbiota plays an important role in host health Fermoy Co., Cork, Ireland and is perturbed by several factors including antibiotics. Antibiotic‐induced changes 3APC Microbiome, Cork, Ireland in microbial composition can have a negative impact on host health including Correspondence reduced microbial diversity, changes in functional attributes of the microbiota, Catherine Stanton, Teagasc Food Research formation, and selection of antibiotic‐resistant strains making hosts more susceptible Centre, Moorepark, Fermoy, Co., Cork P61 C996, Ireland. to infection with pathogens such as Clostridioides difficile. Antibiotic resistance is a Email: catherine.stanton@teagasc.ie global crisis and the increased use of antibiotics over time warrants investigation into Funding information its effects on microbiota and health. In this review, we discuss the adverse effects of APC Microbiome Institute Ireland; Science antibiotics on the gut microbiota and thus host health, and suggest alternative Foundation Ireland