人卫微生物肝炎病毒.pptxVIP

人卫微生物肝炎病毒;Hepatitis viruses and diseases they cause;肝炎病毒;Pathogenesis of hepatitis viruses ;甲型肝炎病毒（hepatitis A virus，HAV）;Shape: naked, spherical particle with cubic symmetry. Genome: linear, positive-sense, single-stranded RNA One stable serotype only Transmission: fecal-oral (via contaminated food or water) Stable at low pH Inactivated by high temperature (185°F or higher), formalin, chlorine;HAV的生物学性状;HAV的结构;第9页/共118页;Hepatitis A virus transmission;Pathogenesis ;第12页/共118页;HAV的致病性;NK细胞杀伤作用;Symptomatology;HAV感染的时间进程;HAV感染后的事件典型顺序;甲型肝炎;临床特点;HAV的免疫性; 1988年上海爆发甲肝大流行;Laboratory diagnosis;Prevention; HAV vaccine;Treatment;Lab diagnosis;Prevention;Hepatitis B Virus ;第29页/共118页;Shape and structure;第31页/共118页;Small Spherical particles;Tubulose particles;Dane particle;Dane particles;What are Dane particles?;Dane颗粒的结构;;HBV的基因组结构;第40页/共118页;第41页/共118页;HBV的复制;第43页/共118页;HBV的抗原组成;表面抗原（HBsAg）;核心抗原（HBcAg）;e抗原（HBeAg）;HBV的其它生物学性状;致病性与免疫性;HBV Modes of Transmission; Having sex without condoms with someone who has hepatitis B;You can NOT get hepatitis B by;Pathology of HBV;Clinical outcomes of Hepatitis B infections;致病与免疫机制;致病与免疫机制;第57页/共118页;致病与免疫机制;致病与免疫机制;致病与免疫机制;免疫应答强弱与临床表现及转归关系;病毒变异与免疫逃逸;HBV与原发性肝癌;乙型肝炎的特点;Lab diagnosis;HBV Antigen and Antibody detection;HBsAg;HBcAg;HBeAg;anti-HBs;anti-HBe;anti-HBc;HBsAg;PreS1和PreS2抗原;HBeAg;HBcAg;The results analysis of HBV antigen-antibody detection ;病毒抗原抗体系统检测结果分析;血清HBV DNA检测;第80页/共118页;Prevention;Who should get hepatitis B vaccine?;Reducing the possibility of transmission;Hepatitis C virus（丙型肝炎病毒）;Hepatitis C Virus;生物学特性;第87页/共118页;Structure of HCV;HCV电镜照片;HCV的基因结构;;致病性与免疫性;致病性与免疫性;Pathogenesis;第95页/共118页;Lab diagnosis;Treatment;;Prevention;A defective virus, need help from HBV The agent consists of a particle 35 nm in diameter consisting of the delta antigen surrounded by an outer coat of HBsAg. The genome of the virus is very small and consists of a single-stranded RNA Acute self-limited infection, fulminant liver