CD4CD25调节性T细胞在肝移植术后腹腔感染中的表达及其作用（临床医学论文资料）.docVIP

CD4CD25调节性T细胞在肝移植术后腹腔感染中的表达及其作用（临床医学论文资料） 文档信息 ： 文档作为关于“医学心理学”中“皮肤病学与性病学”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文11220字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：CD4CD25调节性T细胞在肝移植术后腹腔感染中的表达及其作用 2 1 材料与方法 3 2 结果 5 1～3：G1～G3 6 3 讨论 7 文2：CD4CD25调节性T细胞与头颈部肿瘤 8 3 TGFβ对CD4+ CD25+ Treg细胞的调节 10 4 VEGF对CD4+CD25+　Treg细胞的调节 11 参考文摘引言： 14 原创性声明（模板） 16 文章致谢（模板） 16 正文 CD4CD25调节性T细胞在肝移植术后腹腔感染中的表达及其作用（临床医学论文资料） 文1：CD4CD25调节性T细胞在肝移植术后腹腔感染中的表达及其作用 【Abstract】 Objective To investigate expression of CD4+CD25+ regulatory T cells in model of abdominal cavity bacterial infection after liver traplantation in rats. Methods Orthotopic liver traplant (OLT， DA to Lewis) models were established by modified Kamada twocuff technique. All rats were randomly divided into 3 groups after operation. Normal saline was injected into abdominal cavity at 3rd day postoperatively in group 1， mixed Bacillus coli liquid in group 2 and CsA at 3 mg/kg per day in group 3. Six recipients were sacrificed 7 days after infection in each group， blood and graft samples were collected for detection of ALT and TB. The levels of Treg and Foxp3 in splee and IL10， TGFβ mRNA in live were detected by flow cytometry and RTPCR， respectively. Results Compared with the level of Treg for ± in group 1， the levels of Treg increased obviously in groups 2 and 3 (± vs ±)， with statistical difference ()， so do the expressio of Foxp3， IL10 and TGFβ mRNA. Although the serum concentratio of AST and TB 7 d in Group 2 was higher than those in Group 1， the Banff scores of grafts in group 2 were lower than those in group 1 (). Conclusio Abdominal cavity bacterial infection after liver traplantation in rats increase expression of Treg， promote the immunosuppressive action and partially alleviate the acute rejection。 【Key words】 Liver traplantation; Abdominal cavity bacterial infection; CD4+CD25+ regulatory T cells; Acute rejection 肝移植已成为终末期肝病及急性肝功能衰竭的有效治疗方法，然而术后创伤及大量激素和免疫抑制药物的应