实例教程：手把手教你计算样本量.docxVIP

实例教程：手把手教你计算样本量作者：张耀文 小玲看了新英格兰医学杂志的一篇文章［1］后，有些地方不明白，于是来找 小咖讨论。 小玲：我觉得这个研究做的棒棒哒，但有一点没看明白，就是原文中统计方 法部分的样本量计算到底写了个啥： We estimated that with a sample size of 2400 patients assigned to receive liraglutide and 1200 assigned to receive placebo, the study would have more than 99% power to detect a betweengroup difference in the three coprimary efficacy end points of the main 56-week trial and in the primary end point of the 2-year extension. 小咖：你没看明白就对了。这段话确实没有讲明白样本量到底怎么计算来的。 你应该去看看这个研究的Protos和1 Supplemental Appendi, x里面应该会详细写 到。因为限于篇幅，有些研究会在正文中省略一些信息。 小玲：那么，哪里能找到这个研究的Protoco和1 Supplementary Apperd呢x ? 小咖：来，跟着我操作。首先搜到新英格兰医学杂志的这篇文章，然后点击①PDF下载这篇文章，再点开②Supplementary Mated。al The NEW ENGLANDJOURNAL of MEDICINEHOME ARTKLES MULTMEDIA * ISSUES* SPECIALTIES TOPICS - FOR AUTHORS-ORIGIMM AATiafA Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight ManagementXaver P?-Sunyei M.D. Azne Astrup MD. D M.Sc.. Ken Fujioka M D. FrankGfeenivay. M.D. AJtedo halpern.MO . Micbel Krempf, M D., Pti D., Dsvitf C V/ lau. U D Ph D , Carelw Fowc.FR C F Ph D. The NEW ENGLAND JOURNAL of MEDICINE HOME ARTKLES MULTMEDIA * ISSUES* SPECIALTIES TOPICS - FOR AUTHORS- ORIGIMM AATiaf A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management Xaver P?-Sunyei M.D. Azne Astrup MD. D M.Sc.. Ken Fujioka M D. FrankGfeenivay. M.D. AJtedo halpern. MO . Micbel Krempf, M D., Pti D., Dsvitf C V/ lau. U D Ph D , Carelw Fowc.FR C F Ph D. On12, M D, Cnnsane 8Pm Jensen MD PnD and John ph widinQ DM torve SOME Ooesity and Preoiaoetes NN8O22-1839 sajdy Oroio( N Engl J Med 2015,373:11-22 |Juty2.20151 DO 101056MEJMoa 1411892 Q Commonts open through Ju^r 8, 2015 Share njftSSQ AMtract AhKie Rererences Cnng Artic les (9f| Comments (10^ Lenert AdransG Search 卜 TOOLS 电 Downoad Cititton Q Slide 孰 ° CME 0 E-Mail Osave O AHicie Alert 口 Reprints O Permissions a Share.*goo*crark Material 下载③Protoco和 1 ?Supplentary Appmdo k如 NEW ENGLAND JOURNAL of MEDICINE ORIGINAL ARHCLE A Randomized, Controlled Trial of 3.0