颈动脉内膜中层厚度与中青年阻塞性睡眠呼吸暂停低通气综合征.docVIP

颈动脉内膜中层厚度与中青年阻塞性睡眠呼吸暂停低通气综合征 【关键词】 阻塞性睡眠呼吸暂停低通气综合征；颈动脉内膜中层厚度；高血压 study on the relationship between carotid intima_media thickness and adult obstructive sleep apnea hypoventilation syndrome. zhang zong_hui, zheng liang_yong, fu ying， et al. department of cardiology，the first affiliated hospital of medical college, zhejiang university, zhejiang 310003，china ［abstract］ objective to explore the relationship between carotid intima_media thickness (imt) and adult obstructive sleep apnea hypoventilation syndrome(osahs)． methods blood pressure at 7：00am，apnea hypoventilation index(ahi),the lowest arterial oxygen saturation( lsao2)，and carotid imt were measured in 39 adult patients with osahs. among them，19 patients were hypertension. healthy people with matched age，*** and body mass index (bmi)were chosen as control group. the carotid imt was evaluated in all subjects. results the carotid imts were significantly increased in the moderate and severe adult osahs patients pared with mild patients and normal people（p＜0.01），and were more significant in the osahs patients with hypertension than those without osahs（p＜0.01）． conclusions vascular morphologic change has already been existed in the moderate and severe adult osahs patients；the trend of which could be more significant after developing hypertension． ［key words］ obstructive sleep apnea hypoventilation syndrome； carotid intima_media thickness； hypertension 中青年阻塞性睡眠呼吸暂停低通气综合征(osahs)临床较常见，研究显示：在中青年患者中合并高血压有着比老年患者更强的相关性［1］，而高血压和颈动脉内膜中层厚度（imt）密切相关。有报道证实osahs与颈动脉imt相关［2 ，3］。但国内有关颈动脉imt与中青年osahs关系的临床报道较少，作者分析了近年收集的此类患者的临床资料，以探讨颈动脉imt与中青年osahs的关系。 1 资料与方法 1.1 一般资料：选用xx年3月至xx年12月间经多导睡眠图检测确诊的osahs患者39例,均为中青年男性患者,年龄(45±7.14)岁，身高 (170.23±10.75)cm，诊断分级标准采用第6版《内科学》标准［4］。高血压诊断参考《中国高血压防治指南》标准［5］，同时选择年龄、体重指数相匹配的正常人38例作为对照组；全部研究对象除外癌症，心肌梗死，急性脑血管病，肾脏疾病，胶原血管性疾病等。 1.2 观察指标：osahs患者准确测定呼吸暂停低通气指数（ahi）及最低氧饱和度(lsao2)值，并根据ahi及lsao2将患者分为轻度组(ahi 5～20次／小时；lsao2 85～89%)，中度组(ahi 21～40次／小时；lsao2