内源性调节性T细胞在SAH后脑血管痉挛与脑损伤中的作用.ppt

谢谢观赏 Make Presentation much more fun 内源性调节性T细胞在SAH后脑血管痉挛及脑损伤中的作用 * 研究的目的及意义 SAH后脑血管痉挛、炎症反应及神经功能预后的改善是 一个非常复杂的病理 、生理、临床过程。虽然进行了大量研究， 为止其 发生机制仍未完全明了。研究小鼠体内内源性调节性T细 对SAH后脑血管痉挛、炎症反应及神经功能预后的改善仍 将是今后一个时期的热点。随着研究的逐渐深入，将 会对内源性调节性T细胞移植SAH的临床治疗及神经功能预后带来 深远的影响。 * 国内外相关文献 The Kinetics of Lymphocyte Subsets andMacrophages in Subarachnoid Space After Subarachnoid Hemorrhage in Rats it has been suggested that humoral immunity plays a role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage, there has been no quantitative assay for cellular immunity. We studied the kinetics of immune cells in the subarachnoid space after subarachnoid hemorrhage in the rat. * A serial response of immunoreactive cells, which resembles that of the chronic allergic reaction observed in autoimmune diseases or delayed-type hypersensitivity, exists in the subarachnoid space after subarachnoid hemorrhage. The present results suggest that the initial response in cellular immunity, which is followed by humoral immunity and eicosanoid reactions, plays a role in eliciting the development of cerebral vasospasm. * 蛛网膜下腔出血后脑血管痉挛分子机制的研究进展 与NO代谢有关的CVS K 通道活性的改变 文氧合血红蛋白的作用本 磷酸二酯酶一V的作用本 NO和ET一1的平衡失调 * 与NO代谢无关的CVS Ras蛋白的作用 前列环素与血栓烷A2失衡 自由基与脂质过氧化物增多 血管加压素的作用 ca 代谢紊乱 * Statin-Induced T-Lymphocyte Modulation and Neuroprotection Following Experimental Subarachnoid Hemorrhage Statins in fl uence immune system activities through echanisms independent of their lipidlowering properties. T cells can be subdivided based on cytokine secretion patterns into two subsets: T-helper cells type 1 (Th1) and type 2 (Th2). Independent laboratory studies have shown statins to be potent inducers of a Th2 switch in immune cell response and be neuroprotective in severalmodels of central nervous system (CNS) disease. This study was the fi rst to evaluate the immune modulating effects of statins in subarachnoid hemorrhage (SAH). *