《9.黏膜免疫 研究生》.pptVIP

黏膜免疫Mucosal Immune;黏膜免疫系统（mucosal immune system）： 直接接触病原体的解剖部位并能够分泌粘液的上皮细胞所覆盖，构成黏膜免疫系统。 广泛分布于呼吸道、胃肠道、泌尿生殖道黏膜下及一些外分泌腺体（唾液腺、泪腺、乳腺）处的淋巴组织。 执行局部特异性免疫功能的主要场所。;The mucosal immune system. The tissues of the mucosal immune system are the lymphoid organs associated with the intestine, respiratory tract, and urogenital tract, as well as the oral cavity and pharynx and the glands associated with these tissues, such as the salivary glands and lachrymal glands. The lactating breast is also part of the mucosal immune system.;黏膜免疫系统与免疫应答 黏膜免疫系统中的固有免疫应答 黏膜免疫系统中的适应性免疫应答 黏膜免疫中的免疫耐受和免疫调节 黏膜免疫与疾病 ;小肠黏膜免疫系统的各种细胞成分和器官化的淋巴组织 ;黏膜免疫系统的特点;一、组成肠相关淋巴组织的固有免疫细胞 二、肠道粘膜相关的固有免疫应答 三、上皮内淋巴细胞杀伤入侵病毒和修复损伤组织;Mucosal lymphoid tissue in the human intestine.;; lntraepithelial lymphocytes express CCR9 and the integrin ?E:?7, which binds to E-cadherin on epithelial cells. They are mostly CD8 T cells, some of which express the conventional ?:? form of CD8 and others the CD8 ?: ? homodimer. CD8 T cells predominate in the epithelium, whereas CD8 T cells predominate in the lamina propria. ; The lamina propria contains lgA-producing plasma cells, lymphocytes, effector T cells, dendritic cells, macrophages, and mast cells. T cells in the lamina propria of the small intestine express the integrin ?4:?7 and the chemokine receptor CCR9, which attracts them into the tissue from the bloodstream. ;黏膜淋巴细胞与上皮细胞相互作用： 黏膜淋巴细胞：位于黏膜上皮细胞间和上皮细胞基底层一侧的T 淋巴细胞，包括固有类T 淋巴细胞和NK细胞。 分布部位特殊、功能发挥受控于上皮细胞表面各类MHC分子与其受体分子间的相互作用。 除了经典的MHC I 类和II 类分子，上皮细胞还表达范围广泛的各种非经典MHC分子，包括TL、HLA-E、MIC-A/-B、MR1和进化上与之高度同源的CD1d 分子，激活多种黏膜淋巴细胞。; TL MHC II MHC I TL MIC- MIC - HLA-E CD1d/ MR1 A/-B A/-B ?-Ga