开同专家会议上课讲义.pptVIP

Ketoacid therapy andCKD metabolic complications;Introduction;Why beneficial effects on metabolic disorders can be expected from SVLPD ;Caloric supply;Effects of SVLPD on carbohydrate metabolism disorders ;Insulin resistance in CKD patients ;Insulin resistance in CKD patients effects on carbohydrate metabolism;Insulin resistance in type II diabetes and in CRF ;In vivo exploration of glucose metabolism : the tools;Plasma glucose and Insulin after oral glucose load before and after 3 months on SVLPD L.Baillet et col., Metabolism 2001;Evolution of the insulin level and of the amount glucose infused during the euglycemic hyperinsulin clamp in nondiabetic uremic patients before and after SVLPD Aparicio M. et al. Kidney Int, 1989; Keto Acids Therapy improves the metabolic clearance rate of insulin and reduces hyperinsulinemia which is associated with multiple risk factors for atherosclerosis GIN H. et al Am.J.Clin.Nutr.1994 ;SVLPD and substrate oxidation rate Rigalleau Kidney Int.1997 ; REE and SVLPD in uremia Rigalleau Kidney Int. 1997;SVLPD and endogenous glucose  production (EGP) Rigalleau Am.J.Clin.Nutr.1997;Insulin resistance : other effects ;Copyright ?2002 American Society of Nephrology;Mechanisms of improvement of insulin resistance by SVLPD;Effects of SVLPD on  secondary hyperparathyroidism;Factors of 2nd HPT;P;Consequences of 2nd HPTand hyperphosphatemia;*;Parameters ;;Design: No. of patients: n = 21 Creatinine serum: 6.5 mg/dl Diet: VLPD (0.3 g/kg bw/d) + AA/KA + 2-4 g CaCO3 Duration: 4 ? 2 months;Keto Acid Therapy Phosphate-Calcium metabolism disorders;Improvement in osteofibrotic and osteomalacic changes after 12 months of treatment with a Keto Acid Therapy. M.H Lafage et al. Kidney Int.1992;Evolution of h