OIE《水生动物疫病诊断手册》鲤春病毒血症病毒2018版2.3.9章.pdfVIP

C H A P T E R 2 . 3 . 9 . S P R I N G V I R A E M I A O F C A R P 1. Scope1 Spring viraemia of carp (SVC) is a rhabdovirus infection capable of inducing an acute haemorrhagic and contagious viraemia in several carp species and of some other cyprinid and ictalurid fish species. For the purpose of this chapter, SVC is considered to be infection with spring viraemia of carp virus (SVCV). Comprehensive references can be found in reviews by Wolf, 1988, Ahne et al., 2002and Dixon, 2008. 2. Disease information 2.1. Agent factors 2.1.1. Aetiological agent, agent strains The aetiological agent of SVC is Spring viraemia of carp virus (SVCV), a species in the genus Vesiculovirus in the virus family Rhabdoviridae (Carsten, 2010). The virus genome is a non-segmented, negative-sense, single strand of RNA. The genome contains 11,019 nucleotides encoding five proteins in the following order: a nucleoprotein (N), a phosphoprotein (P), a matrix protein (M), a glycoprotein (G) and an RNA-dependent, RNA polymerase (L). The genome does not contain a non-virion (NV) gene between the G and L genes as is found in fish rhabdoviruses of the genus Novirhabdovirus (Ahne et al., 2002). The type strain of SVCV is available from the American Type Culture Collection (ATCC VR-1390) . Two complete genome sequences of the type strain have been submitted to Genbank (Genbank accession U18101 by Björklund et al., 1996and Genbank accession AJ318079 by Hoffmann et al., 2002). The complete genome sequence of isolates from China (People’s Rep. of) has also been deposited in Genbank (Genbank accession DQ097384 by Teng et al., 2007and Genbank accession EU177782 by Zhang et al., 2009). Stone