ad诊断标准新进展.pptVIP

AD的诊断标准新进展 ;AD的诊断标准;定　义;定　义;定　义;回顾与解读Review: Dementia;精神疾病统计诊断手册（DSM-IV） ;DSM-IV 对痴呆的描述Dementia in DSM-IV;NINCDS-ADRDA阿兹海默病临床诊断标准;痴呆的核心诊断标准;2007年修订的NINCDS-ADRDA标准;2007年修订的NINCDS-ADRDA标准;2007年修订的NINCDS-ADRDA标准;2007年修订的NINCDS-ADRDA标准; CRITERIA FOR AD DEMENTIA – June 11, 2010 ;Alzheimer’s Disease Dementia Workgroup; 2007年前诊断标准的不足之处;引言;传统标准—不合适之处;NINCDS-ADRDA 修订标准（ – June 11, 2010 ）;;I. 全病因所致痴呆的诊断标准（cont.）;I. 全病因所致痴呆的诊断标准（cont.）;I. 全病因所致痴呆的诊断标准（cont.）;II. AD的诊断标准;遗忘症状;(2)非遗忘症状;;分级诊断;A.可能（ Probable ）AD;以下三个方面的因素可以加强对“可能”的AD的诊断力度;1)有记录的功能衰退:;??下三个方面的因素可以加强对“可能”的AD的诊断力度;2)生物学标记阳性:;;Positron Emission Tomography (PET): Glucose Metabolism;PET AND GENETIC RISK FOR AD;FDDNP PET in AD, FTD and normal aging;FDDNP in AD, MCI and NC;PIB and FDG Distribution;;;;;以下三个方面的因素可以加强对“可能”的AD的诊断力度;3)转运子突变:;B. “可疑”的AD;C. 不能诊断为AD;AD的新旧标准;卒中与认知：血管性痴呆Stroke and Cognition: Vascular Dementia;Evolution of the Concept and Treatment of Vascular Dementia (VaD);Vascular Disease and End-Organ Damage;The brain as a cognitive organ is a major target for vascular risk factors;VaD Risk Factors;Diagnosis of VaD:The NINDS-AIREN Criteria;Diagnosis of VaD:The Hachinski Ischemia Score ;;Prevalence and Epidemiology of VaD; Final Common Pathway;Stroke and Dementia;Stroke and Dementia;Multiple large vessel infarcts;Neurological signs and symptoms;AD vs. VaD: “Classical” Clinical Features;;;Emerging view of VaD and AD;血管性痴呆的胆碱能假说;Cholinergic Deficit in VaD;