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47 1 Vol.47 No.1 2018 1 Applied Chemical Industry Jan.2018 ，，，，， （ ， 710021） ：，，（B-CTS）。 、 、、pH ，。 ， ：70 ℃，pH ＝6，1.30 g，4 h。 ，92.93％。 B-CTS ，。 ：；；；；；； ：TQ 281；TQ 314.1；TQ 317 ：A ：1671 －3206（2018）01 －0100 －06 Application of response surface methodology in process optimization for chitosan Schiff ’s base GUO Rui ，GUO Yu ，SONG Bo ，MA Lan ，TU Rui-xiang ，WANG Ying-yue （MOE Key Laboratory of the Chemistry and Technology of Light Auxiliary Chemicals ， Shaanxi University of Science and Technology ，Xi’an 710021，China） Abstract ：Using ethanol as solvent ，chitosan benzaldehyde Schiff ’s base（B-CTS） was performed by the reaction between the 2-amino group of glucosamine residue of chitosan with benzaldehyde .The condensa- tion rate was influenced by the reaction temperature ，the dosage of benzaldehyde ，the reaction time，pH value and solvent amount.Selected the significant effect on the condensation rate by single -factor experi- ment ，the B-CTS process parameters was optimized by Box-Behnken experimental designs in response sur - face methodology.By using Box-Behnken experimental designs in response surface methodology ，the opti- mum condition is：the reaction temperature 70 ℃，pH value ＝6 ，the dosage of benzaldehyde 1.30 g，the reaction time 4 h.Under these optimum conditions ，the condensation rate was 92.93％.Meanwhile，the quadratic regression equation was established and can predict the experimental results effectively . Key words ：chitosan； Schiff ’ s base； amino protection； response surface method ； optimization； model； polymers ， ， 、、、、、 ，