灵芝孢子和抗性淀粉对糖尿病大鼠糖脂代谢及氧化应激的-食品科学.PDF

288 2014, Vol.35, No.23 食品科学 ※营养卫生 灵芝孢子和抗性淀粉对糖尿病大鼠糖脂代谢及 氧化应激的协同干预 姜余梅，杨 艳，陈晓姗，周中凯* （天津科技大学食品工程与生物技术学院，天津 300457 ） 摘  要：目的：探讨灵芝孢子和抗性淀粉对Ⅱ型糖尿病大鼠糖脂代谢及氧化应激的作用和机制。方法：采用链脲佐 菌素诱导的方法建立Ⅱ型糖尿病模型，考察灵芝孢子和抗性淀粉对糖尿病大鼠的血糖、血脂及氧化应激指标的影 响。结果：抗性淀粉和灵芝孢子均可改善糖尿病大鼠血糖水平，对抗糖尿病引起的氧化应激损伤。抗性淀粉降血 糖、抗氧化作用较强，灵芝孢子粉调节大鼠脂代谢紊乱效果明显，抗性淀粉和灵芝孢子协同作用可进一步改善脂代 谢水平，增强二者抗氧化能力。结论：抗性淀粉和灵芝孢子粉协同干预模式和传送方式可有效降低糖尿病大鼠的血 糖水平，改善脂代谢紊乱，提高抗氧化应激的能力，可作为一种较好的减缓糖尿病症状的有效饮食干预方法。 关键词：抗性淀粉；灵芝孢子；糖尿病；血糖；血脂；氧化应激 Synergistic Intervention of Resistant Starch and Ganoderma lucidum Spore Powder on Glycolipid Metabolism and Oxidative Stress in Diabetic Rats * JIANG Yu-mei, YANG Yan, CHEN Xiao-shan, ZHOU Zhong-kai (School of Food Engineering and Biological Technology, Tianjin University of Science and Technology, Tianjin 300457, China) Abstract: Objective: To investigate the mechanism of action of resistant starch (RS) and Ganoderma lucidum spore powder (GLSP) on glycolipid metabolism and oxidative stress in type 2 diabetic rats. Methods: Diabetic rats were induced by streptozocin (STZ). The effects of RS and GLSP on blood glucose, blood lipid and oxidative stress index were investigated. Results: RS and GLSP could improve the content of blood glucose and exert antioxidant effect. While RS had stronger antioxidant capability than GLSP, GLSP had an advantage in improving lipid metabolism disorder over RS and there was a synergistic effect between them. The antioxidant capacity was further enhanced through the intervention with RS. Conclusion: The mode of synergistic intervention and simultaneous consumption of RS and GLSP can effectively reduce blood glucose, improve lipid metabo