三苯胺基衍生物化学荧光探针的合成构效关系及生物学应用研究应用化学专业论文.docxVIP

AbsrtactAbStraCt Absrtact AbStraCt Triphenylamine(TPA)，which is s觚ctured a star-like geomeny w汕a nitrogen atom in me center，is widely used in photoelec仃ic materials and hole-tmsponing materials due to its unique仔ee radicals，la唱er steric hindrance factors，super conjugate elec仃onic e毹ct aJld hi曲hole mobilit)r．Three benzene血gs linked wim the nitrogen atom of triphenylamme，with its obVious actiVi吼stmctural diVersit)r and easily modified proper吼can be coImected with eXtemal substituents at appropriate positions and a series of luminescent materials with certain mnctions can be produced． With a comprehensiVe survey of application studies of triphenylamine nuorescent probe， we haVe prep2ured triphenylamine f0册ylation deriVatiVes mrou曲 the Ⅵlsmeier_Haack reaction and obtamed a series of intemediate compounds through the multistep reaction．BaSed on mese intemediates，a list of noVel triphenylamine Schi行base compounds have been syntlles泣ed by me Witting reaction． T}le recognition abilit)，toward metal ions were studied systematically，and explored me biological印plications combined with me experiment results． The main research contents arc as follows： 1、With仃iphenyl锄ine as donor center， on the one hand，we in仃oduced isophorone red launch伊oup through condensation reaction，on t11e otller hand， corulected the diaminomaleonitrile or miosemicarbazide as me recogllition groups containing multiple ligand atoms，to constmct two new Schifr base fluorescent probes Lw and Lo．Wb studied t11eir recognition abili够toward metalions by ul心aviolet and fluorescence spectrum analysis memods．The experiment results showed tllat tlle probes were able to real—time monitor Cu2+in acetonitrile solution V胁displaying tlle “tum．on’’emission with high selectivi吼sensitiVi够．Su印risiIlgly，me compound Lo possesses two independently aildressable photochromic systems based on the distinct mechanisms in tetrahydro缸an solution a11d solid s协te uIlder me stimuli of删s Ⅲ 万方数据 三苯胺基衍生物化学荧光探针的合成、构效关系及生物学应用研究 三苯胺基衍生物化学荧光探针的合成