氟尿嘧啶长循环热敏脂质体的制备、表征和质量评价-药剂学专业论文.docxVIP

独创性声明 本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成 果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或 集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文 中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。 学位论文作者签名： 日期： 年 月 日 学位论文版权使用授权书 本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权 保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借 阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进 行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。 本论文属于 必威体育官网网址□ ，在 年解密后适用本授权书。 不必威体育官网网址□。 （请在以上方框内打“√” ） 学位论文作者签名： 指导教师签名： 日期： 年 月 日 日期： 年 月 日 目 录 HYPERLINK \l _bookmark0 英文缩写对照表····························································································· 1 HYPERLINK \l _bookmark1 摘 要·········································································································· 2 HYPERLINK \l _bookmark2 ABSTRACT 3 HYPERLINK \l _bookmark3 前 言·········································································································· 4 HYPERLINK \l _bookmark4 第一章 氟尿嘧啶长循环热敏脂质体的处方前研究 ·············································· 9 HYPERLINK \l _bookmark5 1.1 FU 含量测定方法学的建立······································································10 HYPERLINK \l _bookmark6 1.2 FU-LCTSLs 包封率测定方法的建立 14 HYPERLINK \l _bookmark7 1.3 讨论 ···································································································15 HYPERLINK \l _bookmark8 第二章 氟尿嘧啶长循环热敏脂质体的制备、表征和质量评价 ·····························17 HYPERLINK \l _bookmark9 2.1 脂质体制备工艺 ···················································································18 HYPERLINK \l _bookmark10 2.2 脂质体处方研究 ···················································································19 HYPERLINK \l _bookmark11 2.3 验证及重现性实验 ················································································27 HYPERLINK \l _bookmark12 2.4 理化性质研究·······················································································27 HYPERLINK \l _bookmark13 2.5 稳定性考察··························································································30 HYPERLINK \l _bookmark14 2.