分阶段应用中药配合激素治疗原发性肾病综合征的临床观察-中西医结合临床专业(肾脏病方向)专业论文.docxVIP

成都中医药大学 成都中医药大学 2010 届硕士毕业论文 中文摘要 目的：观察分阶段应用中药配合激素治疗原发性肾病综合征的有效性和安全性。 方法：将50例原发性肾病综合征患者随机分为两组，对照组25例予激素( 强的松) 治疗，并予必要的相关治疗；试验组25例在对照组治疗的基础上分阶段辨证加用 中药治疗。 结果：试验组完全缓解16例，显著缓解6例，部分缓解2例，无效1例；对照组完 全缓解9例，显著缓解8例，部分缓解3例，无效4例；提示试验组疗效优于对照组 ( P0．05) 。试验组不良反应痤疮、五心烦热、面色潮红、精神症状的发生率较对 照组低( P0．05) 。两组复发率比较试验组复发率为22％ ，明显低于对照组35％ ( P0．05) 。两组治疗后24h尿蛋白定量、血浆白蛋白明显改善，试验组优于对照 组。 结论：分阶段应用中药配合激素治疗原发性肾病综合征疗效较好，且能减少不 良反应的发生，降低复发率。中西医结合治疗肾病综合征值得进一步研究推广应 用。 关键词：原发性肾病综合征；激素；分阶段应用中药；中西医结合疗法 Abstract Objective:To investigate the effectiveness and security of treating primary nephrotic syndrome with Traditional Chinese Medicine (TCM) and hormone in application. Method: Randomly divide 50 patients with primary nephrotic syndrome into 2 groups. 25 cases in the comparative group were treated with hormone (prednisone) and relative necessary treatment. Meanwhile anther 25 cases in the experiment group were treated with TCM by phases based on the treatment of the control group. Result:In the experiment group, sixty cases totally relieved,6 cases significantly relieved,2 cases partly relieved and 1 case was ineffective. While in the comparative group they were 9,8,3 and 4 respectively. The result of the later group was better than comparative group(p＜0.05). Side-effects the experiment group (such as acne, hot sensation, reddish complexion, spiritual symptoms) was lower than the comparative group.(P0.05) The recurrence rate in the experiment group was 22% which was significantly lower than the comparative group (35%).(P0.05). After the trearment, the 24-hour proteinuria and plasma albumin were obviously improved in both groups. The treatment result shows that the experiment group was superior to the caoparative one. Conclusion:It was better to treat primary nephrotic Syndrome with traditional Chinese medicine and hormone. What’s more, this method could reduce the side- effects and recurrence rate. So the integrative therapy was worth of further study and application.