当归拈痛汤治疗痛风的正交t值法拆方-中药学专业论文.docxVIP

Orthogonal t value method to disassemble prescription research of angelica induces pain decoction treating gout Abstract Objective：Combined with the orthogonal t value method, using high uric acid hematic disease, pain and inflammation of the animal models between pain soup and angelica disassemble square,cooperate with TCM theory,streamline prescription antioxidant gout, while using gouty arthritis against streamline model of prescription. Method：Choose L12（211）orthogonal table，according to the basic theory of TCM, fixxing liquorice(moderating the property of herbs) is radix glycyrrhizae, notopterygium root＋Divaricate Saposhnikovia Root(acetanilide detumescence)、alisma＋agaric(suits spilled hot)、bugbane＋the root of kudzu vine(Lung teh heat) conduct medicine，put angelica induces pain into 12 dismantling counterpart，in the same doses conditions, choose oxygen benzoxazines acid potassium mice caused by high order model、adenine and chiral ethambutol rats induced by high order model、the pain caused by acetic acid pain model、urate crystals (MSU) of mice acute edema model, etc and evaluate the activity of dismantling counterpart. Use the orthogonal t value method,Combined with Chinese medicine theory streamline prescription;choose gouty arthritis model-sodium dichloroisocya nurate crystallization infuse articular cavity rats gouty arthritis model, with joint synovial pathological changes, IL-1?、IL-8,TNF-a content of joint fluid conduct index, revalue streamline prescription of soup resistance between angelica gout. Results: Angelica came down and hurt soup to have the varying degree of party reduced benzoxazines acid potassium mice caused disease high uric acid level of blood; reduce adenine and chiral ethambutol rats induced by high uric acid level of blood disease; lower body torsion inflammatory caused by acetic acid number, reduce urate crystals (MSU) of mice acute edema. Each index of four drug combination weighting method after the standardization of ort