福建省畲族FTO及SLC30A8基因与2型糖尿病的相关性分析-内分泌学专业论文.docxVIP

9 9 P=0.009), while r of SLC30A8 was associated with T2DM (CC vs. TT ： OR=1.478,P=0.009) but not significantly associated with IGR (CC vs. TT：OR=0.867, P=0.176). (5) The frequencies of genotypes and alleles in FTO (rs8050136) were not found to be significantly different between obesity/overweight group and normal body weight group. Logistic analyses revealed that there was no significant relationship between FTO variance and obesity/overweight after adjusted by age and sex (AA vs. CC：OR=1.117，P=0.332). Conclusions: Polymorphisms in rs8050136 of FTO and rof SLC30A8 were both significantly associated with T2DM in She population，and their variants might influence β -cell function. However, FTO gene might not significantly associated with obesity/overweight, in order to confirm this relationship, much lager simple size must be needed. Key words: FTO gene；SLC30A8 gene; type 2 diabetes；single nucleotide polymorphism 5 5 中英文对照表 英文缩写 T2DM 英文全称 Type 2 diabetes mellitus 中文名称 2 型糖尿病 IGT Impaired glucose tolerance 糖耐量受损 IFG Impaired fasting glucose 空腹血糖受损 IGR Impaired glucose tolerance 糖调节受损 NGT Normal glucose tolerance 糖耐量正常 OGTT oral glucose tolerance test 口服葡萄糖耐量试验 GWAS Genome-wide association studies 全基因组关联研究 SNP Single nucleotide polymorphism 单核苷酸多态性 FTO Fat mass and obesity associated 脂肪量和肥胖相关基因 SLC30A8 Zinc transporter-8 gene 锌转运体- 8 基因 BMI Body mass index 体重指数 SBP Systolic blood pressure 收缩压 DBP Diastolic blood pressure 舒张压 FBG Fasting blood glucose 空腹血糖 2hPG 2 h plasma glucose after glucose load 糖负荷后 2 小时血糖 FINS Fasting insulin 空腹胰岛素 TC Total cholesterol 总胆固醇 TG Triglycerides 甘油三脂 HDL-C High density lipoprotein - cholesterol 高密度脂蛋白胆固醇 LDL-C Low density lipoprotein - cholesterol 低密度脂蛋白胆固醇 2 2 学位论文原创性声明和版权使用授权书 学位论文原创性声明 本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独立进行研究工作所 取得的真实成果。除文中已注明引用的内容外，本论文不含任何其他个人或集体已经发 表或撰写过的作品成果。对本论文的研究做出重要贡献的个人和集体，均已在文中以明 确方式标明。本人完全意识到本声明的法律结果由本人承担。 作者签名（手写）： 导师签名（手写）： 年 月 日  年 月 日 学位论文版权使用授权书 本学位论文作者完全了解学校有关保留、使用学位论文的