【医脉通指南频道】2014+推进研究阿尔茨海默氏症的诊断标准：+IWG-2标准.pdfVIP

Position Paper Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria Bruno Dubois, Howard H Feldman, Claudia Jacova, Harald Hampel, José Luis Molinuevo, Kaj Blennow, Steven T DeKosky, Serge Gauthier, Dennis Selkoe, Randall Bateman, Stefano Cappa, Sebastian Crutch, Sebastiaan Engelborghs, Giovanni B Frisoni, Nick C Fox, Douglas Galasko, Marie-Odile Habert, Gregory A Jicha, Agneta Nordberg, Florence Pasquier, Gil Rabinovici, Philippe Robert, Christopher Rowe, Stephen Salloway, Marie Sarazin, Stéphane Epelbaum, Leonardo C de Souza, Bruno Vellas, Pieter J Visser, Lon Schneider, Yaakov Stern, Philip Scheltens, Jeff rey L Cummings Lancet Neurol 2014; 13: 614–29 In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging–Alzheimer’s See Comment page 532 Association have contributed criteria for the diagnosis of Alzheimer’s disease (AD) that better defi ne clinical Centre des Maladies Cognitives phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This et Comportementales, Institut Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances du Cerveau et de la Moelle to improve the diagnostic framework. On the basis of these refi nements, the diagnosis of AD can be simplifi ed, épinière, Paris, France (Prof B Dubois MD, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological Pro