多发性硬化认知功能障碍的颅脑扩散张量成像和发病机制分析-神经病学专业论文.docxVIP

广州医学院硕士学位论文多发性硬化认知功能障碍的颅脑扩散张量成像和发病机制研究 广州医学院硕士学位论文 多发性硬化认知功能障碍的颅脑扩散张量成像和发病机制研究 PAGE PAGE 4 The brain diffusion tensor imaging and pathogenesis of cognitive impairment in multiple sclerosis Graduate: Zhan Tingting Advisor: Dr. Cong Gao Institute of Neuroscience，2nd Affiliated Hospital of Guangzhou Medical College Guangzhou, 510260, P. R. China Abstract Multiple sclerosis（MS） is a central nervous system inflammatory demyelinating disease, have various clinical manifestations, and is the common disease leading to neurological disability among young adult. Neuropsychological studies have shown that the cognitive impairment is common in MS patients. Overseas studies have reported that incidence of different clinical manifestations of cognitive dysfunction.is 40%-65%, 10% of patients have very serious clinic symptoms. Cognitive dysfunction is an important reason for MS patients leaving an job and seriously affects the life quality of patients , the treatment and prognosis of primary disease. In clinic work, we find that some MS patients have had cognitive impairment while no lesion being found in MRI imaging. MS is an autoimmune disease of central nervous system. The demyelination of nerve fibers is the main pathological basis and result to the white matter damage. Resolution of conventional MRI of the lesions is limited, less able to distinct the different pathological changes of MS, and are not well used to study cognitive function based on the pathological anatomy. DTI is the rapid development of MR technology on the base of the DWI. DTI is mainly used for observation of structural characteristics of white matter fiber. Recent studies suggest that MS patients have diffuse brain damage exiting the normal white matter、widespread gray matter and cortex. These parts of the brain tissue can be reltatively intact myelin, have normal appearance, but axonal injury has occurred. We call these occult lesions. It also can cause varying degrees of motor, sensory and cognitive d