孟鲁司特联合布地奈德预防毛细支气管炎后反复喘息疗效观察.docVIP

孟鲁司特联合布地奈德预防毛细支气管炎后反复喘息疗效观察 　　doi：10.3969/j.issn.1007-614x.2014.15.12 　　摘 要 目的：观察孟鲁司特联合布地奈德预防毛细支气管炎后反复喘息的临床效果。方法：2010年10月-2012年10月收治毛细支气管炎患儿60例，作为研究对象，随机分为对照组和观察组，出院后观察组给予孟鲁司特联合布地奈德治疗，对照组则不干预。对两组患儿喘息发生情况进行比较。结果：观察组反复喘息发生率明显低于对照组，差异有统计学意义（P0.05）。结论：口服孟鲁司特联合吸入布地奈德能减少婴幼儿毛细支气管炎后哮喘发生率，疗效确切，应用方便，不良反应小。 　　关键词 孟鲁司特 布地奈德 毛细支气管炎 喘息 　　Curative effect observation of montelukast combined with budesonide in the prevention of repeated wheezing after capillary bronchitis 　　Guan Xue 　　The Maternal and Child Health Hospital of Hechuan District，Chongqing City，401530 　　Abstract Objective：To observe the clinical effect of montelukast combined with budesonide in the prevention of repeated wheezing after capillary bronchitis.Methods：60 children with capillary bronchitis were selected from October 2010 to October 2012 as the research objects.They were randomly divided into the control group and the observation group.After discharge，the observation group were treated with montelukast combined with budesonide.The control group had no intervention.The occurrence of wheeze in the two groups were compared.Results：The incidence rate of repeated wheezing in the observation group was significantly lower than that of the control group.The difference was statistically significant（P0.05）.Conclusion：Oral montelukast combined with inhalation of budesonide can reduce the incidence rate of asthma after capillary bronchitis in infants.Its curative effect is exact.It is easy to applicate and has less adverse reaction. 　　Key words Montelukast；Budesonide；Capillary bronchitis；Wheeze 　　毛细支气管炎常发病于婴幼儿中，首发症状为支气管以下呼吸道喘憋，随后表现为水肿、支气管痉挛、小气道急性炎症等，部分患儿存在气道慢性炎症，日后数年间喘息反复发作，严重影响婴幼儿健康，加重家庭负担[1]。因此，采取有效措施预防毛细支气管炎后反复喘息具有十分重要的意义。为此，笔者对我院毛细支气管炎患儿采取孟鲁司特联合布地奈德治疗，旨在预防反复喘息或哮喘发作。现报告如下。 　　资料与方法 　　2010年10月-2012年10月收治毛细支气管炎患儿60例，作为研究对象，所有患儿均符合毛细支气管炎诊断标准，排除严重肝肾功能障碍、先天性心脏病等患儿[2]。其中男36例，女24例，年龄2～23个月，平均年龄（6.2±1.0）个月。随机将60例患儿分为对照组和观察组，各30例。两组患儿在年龄、性别等方面差异无统计学意义，P0.05，有可比性。 　　治疗方法：两组患儿均行雾化吸入平喘、抗病毒感染等治疗，出院后对照组未采取任何干预措施。观察组出院后给