Effects and cooperationsof INF_γ and IL_12.ppt

In unity there is strength. Nothing is impossible to a willing heart. Interleukin-12 (IL-12) is capital cytokine in cell-mediated immunity adjustment. Its biological functions involve stimulating T cells and NK cells to secrete Interferon-γ(IFN-γ),inducing CD4+ T cells differentiated into Th1 type cells . Effects of IL-12 1 proliferation and function of activated CTLs(细胞毒T淋巴细胞） and NK cells 2 production of the INF-γ 3 promotes TH1 cell introduction；suppresses TH2 cell function 4 promote cell-mediated immunity 5 promote the differentiation from TH0 to TH0 and secrete IL-2 and INF-γ In the early period of viral infection, IL-12 plays a necessary role. Classification of the INF Interferon first divided into type Ⅰ and type Ⅱ, Ⅰ type was found in another two components, although their total interferon receptor components, but the immunogenicity of the two completely different, so will be further divided into type Ⅰ α and β two types, the former had said leukocyte interferon, which has called fibroblast interferon. Type Ⅱ is to be designated as γ-type, so it is now divided into three categories namely, interferon α, β, γ. Effects of INF-γ 1 induction of class ⅠMHC on all somatic cells 2 induction of class Ⅱ MHC on APCs and somatic cells 3 activation of macrophages，neutrophils and NK cells 4 enhancing the activity of TH1 cells，but inhibits the production of TH2 cells 5 acting on activated B cells to induce inmunoglobulin class switching to IgG1-an isotype 6 synergistically enhance the cytotoxic effects of INF-α 7 INF-γ can stimulate gens translate and express of the complements IFN-γ is a typical Th1-type cytokines, can inhibit the growth of tumor cell lines with macrophage-activating factor of the role, can trigger macrophages to kill tumor effect and enhance cytotoxic T lymphocyte (CTL) and NK cells the ability of anti-target cells and inhibit Th2 cell proliferation Expectations of IL-12 Because IL-12 in anti-tumor immunity and anti-infection immu