Paraxial and Intermediate Mesoderm - Mount Saint Mary College傍轴和中间的中胚层-圣玛丽学院.pptVIP

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Paraxial and Intermediate Mesoderm - Mount Saint Mary College傍轴和中间的中胚层-圣玛丽学院.ppt

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Paraxial and Intermediate Mesoderm - Mount Saint Mary College傍轴和中间的中胚层-圣玛丽学院

Paraxial and Intermediate Mesoderm Mesodermal Regions Into what five regions do we subdivide the mesoderm? prechordal plate mesoderm chordamesoderm paraxial mesoderm (somitic dorsal) intermediate mesoderm lateral plate mesoderm Mesodermal Regions Somite Formation What substance appears to be critical to the specificaton of of somites from paraxial mesoderm? Somite Formation Somites are formed in a periodic manner. What appears to control this periodicity? Somite Formation What role does the Hairy1 gene play in somite formation? Somite Formation What factors influence the conversion of developing somite from mesenchyme to a block of epithelial tissue? Somite Formation What determines specification of somites along anterior-posterior axis? Somite Formation What structures are formed from the somite? cartilage of vertebrae and ribs dermis of dorsal skin muscles of rib cage, back, limbs, abdominal wall and tongue Somite Formation As the somite differentiates what regions become distinctive? Somite Formation What factors cause differentiation of sclerotome? sonic hedgehog Pax1 What factors are responsible for differentiation of dermatome? neurotropin 3 wnt1 Somite Formation What factors influence the determination of the myotome? epaxial myoblasts – wnt1 and 3 hypaxial myoblasts – wnt and BMP shh inhibits BMP signal from converting sclerotome to myoblasts Somite Formation Myogenesis What are myogenic bHLH proteins? Osteogenesis What are the three lineages giving rise to the skeleton? somites – axial skeleton lateral plate mesoderm – limbs cranial neural crest - craniofacial Osteogenesis How is endochondrial ossification different from intramembranous ossification? Osteogenesis What are the different stages of bone formation in endochondrial ossification? Intermediate Mesoderm and Kidney Formation What appears to be needed for kidney formation? Intermediate Mesoderm and Kidney Formation What are the three major stages of mammalian kidney development? Intermediate Meso