毒理学期末论文三氧化二砷抑制人体细胞的作用机理（终稿）.docVIP

三氧化二砷抑制人体癌细胞的作用机理 陈镇威 动科1103 3110100465 金乾昂 动科1101 3110100290 【摘要】三氧化二砷，俗称砒霜，是最古老的之一。农业上用作防治病虫害的杀虫剂，消毒剂和除锈剂，也用作其他含砷杀虫的原料。砒霜对诸多癌细胞存在着明显的抗肿瘤和促进癌细胞凋亡的作用。 尤其对胃癌和肝癌，较低浓度的砒霜可明显诱导胃癌和肝癌细胞凋亡,能选择性地消灭胃癌和肝癌细胞而不损伤血管生成机理端粒酶活性机制mechanism of arsenic trioxide inhibiting human (stomach) cancer cells 【Abstract】Arsenic trioxide, commonly known as arsenic, is one of the oldest poison. As pests on agricultural pesticides, disinfectants and cleaning agents, it’s also used as raw material for other insecticidal pesticides containing arsenic. Excessive use of arsenic can cause the residues in crops, and toxic effects, in recent years, studies have shown that arsenic on anti-tumor there is apparent in many cancer cells and promote the role of apoptosis in cancer cells. Particularly for gastric cancer and liver cancer, lower concentrations of arsenic can induce apoptosis in gastric and liver cancer cells, and it can selectively eliminate stomach and liver cancer cells without damaging normal cells. Anticancer mechanism of arsenic trioxide currently studies at home and abroad there are many by finishing the collection we summarize several points: 1, regulating the expression of apoptosis-related genes, 2, the mechanism of inhibition of angiogenesis; 3, reduced mechanism of telomerase. Believe in future studies will better identify efficient mechanism of arsenic trioxide and better benefit humanity. 【Key words】Arsenic; arsenic trioxide; cancer cells; apoptosis; mechanism; 前言 三氧化二砷( As2O3 )可调节相关基因表达, 降低端粒酶活性, 进而促进人胃癌细胞凋亡,减少肿瘤细胞转移。As2O3 对胃癌移植瘤模型小鼠肿瘤细胞有明显的抑制及凋亡作用。As2O3 治疗胃癌的机制是多途径多靶点的, 其治疗胃癌的前景非常广阔。[1]本文就砷的理化性质、用途以及现阶段内对三氧化二砷抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤新生血管形成以及下调端粒酶活性等方面进行综述。有黄、灰、黑褐三种同素异形体。其中灰色晶体具有金属性，脆而硬，具有金属般的光泽，并善于传热导电，易被捣成粉沫。密度5.727克/厘米3。熔点817℃（28大气压），加热到613℃，便可不经液态，直接升华，成为蒸气，砷蒸气具有一股难闻的大蒜臭味。砷的化合价3和5。第一电离能9.81电子伏特。游离的砷是相当活泼的。在空气中加热至约200℃时，有萤光出现，于400℃时，会有一种带蓝色的火焰燃烧，并形成白色的氧化砷烟。游离元素易与氟和氮化合，在加热情况亦与大多数金属和非金属发生反应。不溶于水，溶于硝酸和王水，也能溶解于强碱，生成砷酸盐。砷在地壳中含量并不大，但是它在自然界中到处都有。砷在地壳中有时以游离状态存在，不过主要是以硫化物矿的形式存在