The Role of Metformin in the Treatment of Insulin Resistance …二甲胍治疗胰岛素抵抗的作用….pptVIP

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2018-06-19 发布于福建
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The Role of Metformin in the Treatment of Insulin Resistance …二甲胍治疗胰岛素抵抗的作用….ppt

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The Role of Metformin in the Treatment of Insulin Resistance …二甲胍治疗胰岛素抵抗的作用…

* Although the criteria for defining hypoglycaemia may vary somewhat, association guidelines provide some guidance for standardisation American Diabetes Association (ADA) Canadian Diabetes Association (CDA) European Association for the Study of Diabetes (EASD) European Medicines Agency (EMA) The UK Hypoglycaemia Study was an observational study over 9–12 months in six UK secondary care diabetes centres. Altogether, 383 patients were involved. Patients were divided into the following three treatment groups for type 2 diabetes (T2D): Sulphonylureas Insulin for 2 years Insulin for 5 years and into two treatment groups for type 1 diabetes (T1D), namely 5 years’ disease duration and 15 years’ disease duration. Self-reported (mild and major) episodes were recorded. Highlighted area links hypo episodes in T1D and T2D – adressing the myth that hypos are less common/ severe in T2D than T1D * * * Abstract: Brod et al. Value Health 2011;14:665–71 Objectives: Hypoglycaemia is a common complication of treatment with certain diabetes drugs. Non-severe hypoglycemic events (NSHEs) occur more frequently than severe events and account for the majority of total events. The objective of this multi-country study was to identify how NSHEs in a working population affect productivity, costs, and self-management behaviors. Methods: A 20-minute survey assessing the impact of NSHEs was administered via the Internet to individuals (over 18 years of age) with self-reported diabetes in the US, UK, Germany, and France. The analysis sample consisted of all respondents who reported an NSHE in the past month. Topics included: reasons for, duration of, and impact of NSHE(s) on productivity and diabetes self-management. Results: A total of 1404 respondents were included in this analysis. Lost productivity was estimated to range from ￡9.90 to ￡60.69 per NSHE, representing 8.3 to 15.9 hours of lost work time per month. Among individuals reporting an NSHE at work (n=972), 18.3% missed work for a