TACE序贯联合CT导向下的RFA和CIK治疗原发性肝细胞癌的随机研究_吴沛宏.pptVIP

TACE Sequentially combined with RFA and cytokine-induced killer( CIKS) infusion for HCCTACE序贯联合CT导向下的RFA和CIK治疗原发性肝细胞癌的随机研究 Authors blocK: WU Pei-Hong(1), XIA Jian-Chuan(2), ZHAO Ming(1), ZHOU Qi-Ming(1), WANG Qi-Jing(2), HUANG Li-Xi(2), LI Yong-Qiang(2), CHEN Shi-Ping(2) Afiliations: 1.Department of Imaging and Interventional Radiology , Cancer Center, Sun Yat-sen University //State Key Laboratory of Oncology in South China 2. Department of Biotherapy, Cancer Center, Sun Yat-sen University // State Key Laboratory of Oncology in South China Introduction前言 Biological characteristics of HCC肝癌的生物特性 Hypervascular tumor 多血供肿瘤 Multiple lesions 多病灶 Multicentric origences 多中心发生 Early portal vein encroachment and liver metastasis 早期门静脉与肝内转移 The present of microscopic lesions 微转移灶的存在 Background of virus hepatitis and cirrhosis Cirrhosis induced mutation of live cells continously 乙肝病毒与肝硬化可引起肝细胞发生基因突变 Background Micrometastases of HCC had been detected by molecular techniques in 88% of patients at the time of surgery 约88%病人在手术时发现微转移 Postsurgical recurrence of HCC is frequent and fatal 术后复发常见且是致命的 Traditional curative hepatic resection is unsuitable for most of HCC patients 传统手术切除对多数肝病人不适合 New Modalites? New Therapeutic Strategy for HCC TACE : Entire therapy in organ-level 器官水平的治疗 RFA: focal intensive therapy 局部广泛治疗 Immunotherapy : clear sub-imaging lesions or micro-lesions and anti-hepatitis virus 清除亚临床病灶、微病灶与抗肝炎病毒 To Evaluate the clinical effects of therapy of TACE sequentially combined with RFA and CIKs transfusion 评价TACE序贯联合CT导向下的RFA和CIK治疗原发性肝细胞癌 的临床效果 To explore a new strategy based on the basic of biologic characteristics of HCC 探讨基于肝癌的生物特性新的治疗肝癌方法 MATERIAL ﹠ METHOD