gnrh受体在米非司酮诱导pcos大鼠垂体中表达及意义-expression and significance of gnrh receptor in pituitary of pcos rats induced by mifepristone.docxVIP

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gnrh受体在米非司酮诱导pcos大鼠垂体中表达及意义-expression and significance of gnrh receptor in pituitary of pcos rats induced by mifepristone.docx

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gnrh受体在米非司酮诱导pcos大鼠垂体中表达及意义-expression and significance of gnrh receptor in pituitary of pcos rats induced by mifepristone

Changes in body weight before and after treatment and the ovaries weight were significantly increased compared with the control group（△body weight：22.2±4.808 VS 11.3±2.697（g）；ovaries weight：53.867±1.571 VS 43.435±2.670（mg/100g body weight））（P0.01）. The levels of T 、LH and E2 in the experiment group were significantly higher than in control group(serum T：0.492±0.095 VS 0.201±0.042（ ng/ml ）； serum LH: 15.571±2.119 VS 10.305±1.678(mIU/ml) ； serum E2 ： 78.850±6.343 VS 71.450±4.146（pg/ml）) (P0.01)，while the level of FSH was lower,but there is no significance (7.592±0.899 VS 8.194±1.281 (mIU/ml))(P=0.094) .In experiment group , can see multiple follicular cysts and atretic follicles, the granule cells layer reduced to 2-3 layers, and the oocytes or corona radiata disappeared. It is also seen the decreased number of corpora lutea with incomplete luteinization. The control group can be seen more complete corpora lutea and different levels of follicles with thicken layer of granulosa cells.The expression of GnRH-R exists in pituitary in both group , and in experimental group, the expression of GnRH-R in pituitary was significantly higher（the value of average optical density : 117.151±6.817 VS 96.315±6.894，P0.05）.the serum T and LH levels were positively correlated with the expression of GnRH-R in pituitary.（r1=0.891，r2= 0.801，P0.05）.Conclusions1．The morphologic and hormonal changes of the ovaries in the mifepristone induced PCOS models were similar to those of the patients with PCOS．It was proved to be anideal PCOS animal model.2．The increased GnRH-R expression might have some relevance with the elevated testosterone and LH and anovulation.Key wordspolycystic ovarian syndrome , GnRH-receptor , pituitary, immunohistochemistry 缩略词表PCOS GnRH GnRH-RE2polycystic ovarian syndrome Gonadotrophin releasing hormone Gonadotrophin releasing hormone receptorEstradiol多囊卵巢综合征促性腺激素释放激素促性腺激素释放激素受体雌二醇FSHFollicle stimulating hormone卵泡刺激素LHLuteinizing hormone黄体生成素TTestosterone睾酮ARAndrogen