生物化学与分子生物学学习课件：蛋白质的生物合成 2.pptxVIP

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生物化学与分子生物学学习课件：蛋白质的生物合成 2.pptx

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PART I: Protein Synthesis Components PART II: Protein Synthesis Process PART III: Protein Synthesis Regulation PART IV: Posttranslational Processing and Targeting PART V: Protein Synthesis in Medicine ; PART IV: Posttranslational Processing and Targeting ;From DNA to protein;4;The macromolecules assisting the formation of protein secondary structure include Molecular Chaperon Protein Disulfide Isomerase(PDI) Peptide ProlylCis-trans Isomerase(PPI);6;Mechanism;GroEL forms two stacked 7-membered rings of 60 kD subunits; GroES is a dome on the top ;9;10;4.2.2 Protein disulfiteisomerases pattern disulfide bonds;The corrective disulfide is very important for the structure of secreted proteins and membrane proteins.;4.2.3 Peptidylprolyl isomerization;Cyclosporine A and Cyclophilin;4.3 Posttranslational Processing and Modifications of Newly Synthesized Polypeptides; ;Methionine aminopeptidase 2;POMC, a polypeptide hormone precursor, is cleaved into different peptide hormones in different tissues.;Posttranslational Modification;Histone Modification;Histone Code Hypothesis;Phosphorylation;Amplification or over-expression of HER2 in 30% breast cancer Therapy: monoclonal antibody trastuzumab (Herceptin) Pertuzumab, which inhibits dimerization of HER2 and HER3 receptors tamoxifen ;Protein GlycosylationCommon in Eukaryotic Proteins;N-Linked Glycans;O-Linked Glycans;The correctly folded proteins need to be transported to special cellular compartments to exert desired biological functions. AAs sequence on the N-terminus that directs proteins to be transported to proper cellular target sites is called signal sequence.;;;;ER membrane;Ribosome dissociates;;;;;D. Nuclear Export Signal;PART V: Protein Synthesis in Medicine;;Online Mendelian Inheritance in Man (OMIM) is a database that catalogues all the known diseases with a genetic component;Uniprot();Ribosomopathies;Congenital Asplenia;Diamond-Blackfananemia(戴-布二氏贫血);Cirrhosis;Shwachman-Bodian-Diamond syndrome(许氏症);Treacher-Co