血糖波动对2型糖尿病合并急性脑梗死患者急性期神经功能影响-effect of blood glucose fluctuation on neurological function in patients with type 2 diabetes mellitus and acute cerebral infarction at acute stage.docxVIP

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血糖波动对2型糖尿病合并急性脑梗死患者急性期神经功能影响-effect of blood glucose fluctuation on neurological function in patients with type 2 diabetes mellitus and acute cerebral infarction at acute stage.docx

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血糖波动对2型糖尿病合并急性脑梗死患者急性期神经功能影响-effect of blood glucose fluctuation on neurological function in patients with type 2 diabetes mellitus and acute cerebral infarction at acute stage

WHOWorld Health Organization世界卫生组织ELISAEnzyme-linked immunosorbent assay酶联免疫吸附法NCNormal control正常对照BMIBody mass index体重指数DBPDiastolic blood pressure舒张压SBPSystolic blood pressure收缩压PKCProtein Kinase C蛋白激酶 CNTNitrotyrosine硝基酪氨酸IL-6Interleukin-6白介素 6IL-8Interleukin-8白介素 8ODoptical density吸光度值SSecond秒minMinute分钟hHour小时mmolMillimole毫摩尔mmMillimeter毫米LLiter升mlMilliliter毫升μlMicroliter微升nmolMillimicromole纳摩ngNanogram纳克2Effects of glucose excursion on neurological dysfunction in type 2 diabetes patientswith acute cerebral infarctionAbstractBackground:Type 2 diabetes mellitus (T2DM) is endocrine and metabolic diseases with disorder of glucose metabolism as the main clinical manifestations . its incidence has increased steadily in the worldwide. Its chronic high blood sugar level can lead to a damage of structural and functional abnormal to a variety of tissues and organs. The macrovascular complications which the cardiovascular and cerebrovascular diseases as representive in patients with T2DM is an important cause of their death and disability. Acute cerebral infarction (ACI) as an extremely important macrovascular complication of diabetes, hasbeen widespread concerned. The fatality rate 、Disability rate and recurernce rate of ACIpatients with T2DM is more higher. Glycemic control have a very important clinical significance for the condition of T2DM patients . It was found that glucose excursion is an independent index compare to glycosylated hemoglobin A1c to evaluate the average level of blood sugar in T2DM patients. In the progress of the study of glycemic control . Under similar condition of glycosylated hemoglobin A1c , glucose excursion level can be significantly different, leading to different types of complications. The the actual situation of glucose excursion in T2DM patients with acute cerebral infarction and its clinical significance is rarely reported nowadays . Based on this background we try to investigate the effects of glucose excursion on neurological dysf