血清视黄醇结合蛋白rbp4水平与胎儿宫内生长发育的关系-relationship between serum retinol binding protein rb p4 level and fetal growth and development in utero.docxVIP

血清视黄醇结合蛋白（RBP）4水平与胎儿宫内生长发育的关系中文摘要目的：通过检测不同胎龄、不同出生体重新生儿血清视黄醇结合蛋白（Retinol-bindingprotein，RBP）4水平和胰岛素（Insulin,INS）水平，探讨血清RBP-4在胎儿宫内生长发育、营养代谢中可能起到的作用及其可能的机制，为新生儿宫内发育的评估提供新指标。方法：选取2010年3～5月山西省儿童医院新生儿科住院足月新生儿共89例，按照出生体重与胎龄的关系分为3组，即小于胎龄组(smallforgestationalage,SGA)30例、适于胎龄组(appropriateforgestationalage,AGA)30例、大于胎龄组(largeforgestationalage,LGA)29例，均为轻度羊水吸入和咽下综合症的患儿。采集出生后24小时内的股静脉血5ml，用酶联免疫法(ELISA)检测89例新生儿血清中RBP-4和INS水平，并详细记载其出生体重，按出生体重评估新生儿宫内的营养状态，应用SPSS17.0软件进行统计分析，以p＜0.05为有统计学意义。结果：1、足月新生儿SGA、AGA、LGA3组血清RBP-4水平有显著差异，AGA组血清RBP-4水平高于SGA组，LGA组血清RBP-4水平高于AGA组。2、足月新生儿SGA、AGA、LGA3组血清INS水平有显著差异，AGA组血清INS水平高于SGA组，LGA组血清INS水平高于AGA组。3、血清RBP-4水平与新生儿出生体重呈显著正相关。4、血清INS水平与新生儿出生体重呈显著正相关。5、足月新生儿血清RBP-4水平与INS水平呈显著正相关。结论：RBP-4参与了胎儿宫内生长发育的调节，其机制可能通过影响INS的水平，对胎儿宫内的生长发育起调节作用。关键词：视黄醇结合蛋白4；胰岛素；新生儿；宫内生长发育英文摘要Serumretinolbindingprotein4levelsandtherelationshipbetweenfetalgrowthanddevelopmentAbstractBytestingdifferentgestationalage,birthweightinfantsindifferentserumretinolbindingprotein4levelsandinsulinlevelsofserumRBP-4infetalgrowthanddevelopment,nutritionmayplayaroleinmetabolismandthepossiblemechanismfortheevaluationofintrauterinedevelopmentofnewindicatorsMethodSelectShanxiProvincefromMarchtoMay2010DepartmentofNeonatologyChildren’sHospitalatotalof89patientshospitalizednewborns,accordingtotherelationshipbetweenbirthweightandgestationalageweredividedinto3groups,30casesofsmallforgestationalage（SGA）children,30casesofappropriateforgestationalage（AGA）children,29casesoflargeforgestationalage（LGA）children,weremildinhalationandingestionofamnioticfluidsyndromeinchildren.。Collectedwithin24hoursafterbirth,thefemoralvein5ml,detectedbyELISAin89casesofneonatalserumRBP-4andINSlevels,anddetailedrecordsoftheirbirthweight,birthweightaccordingtointrauterinenutritionalstatusassessment,ApplicationSPSS17.0softwareforstatisticalanalysistop＜0.05wasconsideredstatisticallysignificant.Results1、Full-termnewbornsSGA,AGA,LGA3serumRBP-4levelsweresignificantlydifferent,AGAserumRBP-4levelshigherthantheSGAgroup,LGAserumRBP-4level