动脉硬化血栓病理生理学教学课件.ppt

34062 Atherothrombosis v21 Atherothrombosis Pathophysiology What Is Atherothrombosis? The formation of a thrombus on an existing atherosclerotic plaque Atherothrombosis is a new term recognizing that atherosclerosis (plaque development) and acute thrombosis are integrally related to the presentation of vascular events A generalized progressive disease of large- and mid-size arteries that affects multiple vascular beds, including cerebral, coronary, and peripheral arteries The underlying disease leading to myocardial infarction (MI), peripheral arterial disease (PAD), ischemia and many forms of stroke Atherothrombosis* is theLeading Cause of Death Worldwide1 Atherothrombosis Significantly Shortens Life Hospitalizations in the USDue to Vascular Disease Preventable Deaths Epidemiology of ACS in the United States Single largest cause of death 515,204 US deaths in 2000 1 in every 5 US deaths Incidence 1,100,000 Americans will have a new or recurrent coronary attack each year and about 45% will die* 550,000 new cases of angina per year Prevalence 12,900,000 with a history of MI, angina, or both Epidemiology of Stroke in the United States Prevalence 4.7 million cases Incidence 700,000 new or recurrent strokes each year Morbidity/mortality Third leading cause of death 1 of every 14 deaths (?168,000 deaths) Stroke: a leading cause of long-term disability Peripheral Arterial Disease PAD affects 12% of the adult population1,2 20% of the population aged 70 Associated with 6-fold increase in CV mortality3 Underrecognized and undertreated4 Measurement simple, inexpensive, and noninvasive Appropriate for risk assessment and screening Patients at high risk need aggressive risk-factor modification and antiplatelet drugs4 Diabetes: Impact in United States 12 million people with diabetes1 Diabetes is the 5th leading cause of death1 Half of diabetic patients will experience kidney failure1 Diabetes is the leading cause of new adult cases of blindness2 Direct and indirect di