内皮功能和心血管危险因素_薛增明.pptVIP

* Superoxide measured 3 hours after morning dose of ISMN (200 mg/kg/day) (Huge dose; nitrate tolerance) * * * * * * * * * * * * * * * * * * * * Had positive SPECT scan. * * * * * * Why did some trials show vitamins to be detrimental? * * Why did some trials show vitamins to be detrimental? * * * * It is important to know that the significance of NO release from the endothelium is much less likely its dilator effects as it is the antiatherosclerotic effects of NO. Interestingly EETs share many of the same properties of NO in this respect. So one might argue that EET/EDHF is a better antiatherosclerotic agent than NO because it is not inhibited by superoxide and disease states as easily as is NO. This hypothesis has indirect support from two different observations. * * It is important to know that the significance of NO release from the endothelium is much less likely its dilator effects as it is the antiatherosclerotic effects of NO. Interestingly EETs share many of the same properties of NO in this respect. So one might argue that EET/EDHF is a better antiatherosclerotic agent than NO because it is not inhibited by superoxide and disease states as easily as is NO. This hypothesis has indirect support from two different observations. * Superoxide measured 3 hours after morning dose of ISMN (200 mg/kg/day) (Huge dose; nitrate tolerance) * * 7 patients with endstage PVD underwent autologous mononuclear BM transplantation * * * * * * * * * * * * * FMD is a fundamental mechanism of increasing vascular diameter in blood vessels and the most important physiological mechanism of vasodilation. The basic concept is that flow through a vessel exerts shear stress on the underlying endothelium. Through mechanical activation, this releases vasoactive compounds that then diffuse to the underlying smooth muscle and elicit vasodilation. The best known of these substances is NO that is the major factor released from conduit vessels. In addition to dilation NO plays a very importa