复方丹参注射液治疗急性胰腺炎临床研究.docVIP

复方丹参注射液治疗急性胰腺炎临床研究 　　【摘要】 目的 观察复方丹参注射液在治疗急性胰腺炎中的临床疗效,了解复方丹参注射液对急性胰腺炎(AP)患者血浆内皮素(ET)浓度的影响,对改善微循环的作用。方法 将100例AP患者随机分为对照组(40例)和治疗组(60例),对照组采用常规治疗,治疗组采用常规治疗+复方丹参注射液治疗,以放射免疫法(RIA)测定血浆ET浓度。结果 两组病例除了腹痛消失时间无显著性差异外(P0.05),腹部压痛消失、血尿淀粉酶、影像学恢复和平均治疗时间治疗组均短于对照组(P 　　【关键词】 急性胰腺炎;内皮素;复方丹参注射液 　　 　　The Clinical Study on CO.SalviaMiltiorthizae.Injection in the Treatment of Actute Pancreatitis 　　 　　ZHANG Jin-tang, ZOU Jin-lin.The Fifth Affiliated Hospital of Sun Yet-Sen University,Zhuhai 519000,China 　　【Abstract】 Objective To study clinical effects ofCO.SalviaMiltiorthizae(CSM) on Actute Pancreatitis,the changes of plasma endothelin(ET) as well as the role on the microcirculation of patients with acute pancreatitis(AP).Methods A total of 100 patients with AP was divided into contrast group (group A)(n=40)and treat treatment group(group B) (n=60),treated with routine method(group A)and CO.SalviaMiltiorthizae.injection added routine method,respectively.The levels of plasma ET were measured by radioimmunoassay.Results The average time of abdomen tenderness,amylase and shaperesume natural and treatment were significantly shorter in group B than in group A,but the average time of bellyache evaporating were notsignificantlydifferentialin the two groups.After 7 days treatment,the levels of ET in group A were slightly decreased compared with those before treatment(P0.05),while the levels of ET in group B were obviously decreased compared with those be fore treatment[(61.89±7.14)ng/L vs (104.41±7.88)ng/L,P[1]标准。按照平行对照设计原理,将所有患者分为常规治疗组(对照组,40例)和常规治疗+复方丹参注射液治疗组(治疗组,60例)。两组APACHE评分分别为(13.21±1.22)分、(13.67±1.81)分,无显著性差异(P0.05)。 　　1.2 治疗及检测方法 对照组:采用常规治疗,住院后即给予禁食、禁水、胃肠减压、抑制胃酸和胰腺分泌、止痛、抗感染、营养支持和维持水电解质平衡。 　　治疗组:在常规治疗的基础上,给予复方丹参注射液(3 g生药/2 ml)10~20 ml加入5%~10%葡萄糖注射液250 ml内静脉滴注,1次/d。所有患者均在入院诊断明确后及用药前静脉取血,首次取血于患者住院后24 h内完成,然后治疗D3、D5和D7后取空腹静脉血检测肝功能、血常规和血淀粉酶及晨尿检测尿淀粉酶,D1、D3和D5复查胰腺B超,D1和D7复查胰腺B超及血浆ET浓度。血浆ET浓度采用放射免疫法测定,仪器为CAP216放免仪,放免试剂盒由北京北方生物技术研究所提供,复方丹参注射液为上海第一生化药业有限公司产品(批准文号:国药准字。 　　1.3 统计学