急性淋巴细胞白血病低危组复发儿童临床相关性分析-clinical correlation analysis of relapsed children in acute lymphoblastic leukemia low-risk group.docxVIP

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急性淋巴细胞白血病低危组复发儿童临床相关性分析-clinical correlation analysis of relapsed children in acute lymphoblastic leukemia low-risk group.docx

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急性淋巴细胞白血病低危组复发儿童临床相关性分析-clinical correlation analysis of relapsed children in acute lymphoblastic leukemia low-risk group

AbstractObjective:Thispaperaimstoanalyzethechemotherapydataofchildhoodacutelymphoblasticleukemia(ALL)inlow-riskgroupintheAffiliatedHospitalofQingdaoUniversityandtoexploretherelevantfactorsofrecurrenceinthelow-riskchildrengroup.Methods:SelectingcaseswerediagnosedasB-typelow-riskgroupfromMay1,2005toApril30,2009inpediatrichematologyofourhospitalthroughretrospectivestudyandweretreatedwiththeschemeofShanghaiChildren’sMedicalCentre-AcutueLymphoblasticLeukemia-2005.IntheendofSeptember30,2011,thestudyhasexcludedtheabandonedandlostfollow-upcasesandmadeastatisticanalysiswiththerestofdata.Thestudycontains45casesdiagnosedasB-typelow-riskALL,amongofwhich,recurrencegroupwasconsistedof6cases,3malecasesand3femalecasesrespectively.Intherestof39cases,6caseswiththesamegenderandsimilarbodysurfaceareaswereselectedascontrolgrouptocollectandprocessclinicaldata.IndependentsampleT-testwascarriedouttoanalyzethedifferencesamongthemeanvalueoftestsamples.AllthedatainthestudyareprocessedbySPSS17.0.Results:1.Thecomparisonofclinicaldatabetweenrecurrencegroupandcontrolgroupbeforetreatment:therewerenosharpdifferences(Pvalue0.05)ingeneralconditionofattack,fusiongenandchromosome.2.TreatmentCondition:(1)Mperiod:Thetreatmentdurationofrecurrencegroupwasmuchlonger(p=0.047).(2)Infectionfrequency:recurrencegrouphasincreasedrapidly(p=0.049)inCs1,while,durationofanti-infectiontherapywasnosharpdifferencesinthefirstthreephases(Pvalue0.05).3.Thenumberoflumberpunctuateandbloodinfusion:therewerealsonoobviousdifferencesinthenumberoflumberpunctuate,infusionofredbloodcellsandplatelets(Pvalue0.05).4.Theutilizationofchemotherapydrugs:Inthefirstthreemonths,theintensityutilizationofcytarabine,6-mercaptopurineandmethotrexateofrecurrencegroupwasmuchlowerthantheintensityofthatofcontrolgroup(Pvalue0.05).Conclusion:1.AsfortreatmentdurationinMperiod,therecurrencegroupismuchlongerthancontrolgroup,whichindicatestheextensionoftreatmentdurationinMwouldcauserecurrence.2.Thetimeofinfectionfrequencyofrecurrencegroupismuchmorethanthat