Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity推荐.pdfVIP

NIH Public Access Author Manuscript J Am Chem Soc. Author manuscript; available in PMC 2014 June 19. N Published in final edited form as: I H J Am Chem Soc. 2013 June 19; 135(24): 9139–9148. doi:10.1021/ja403523p. - P A A u Coupling protein engineering with probe design to inhibit and t h o image matrix metalloproteinases with controlled specificity r M a † † ‡ † † n Montse Morell , Thinh Nguyen Duc , Amanda L. Willis , Salahuddin Syed , Jiyoun Lee , u † § † § || s Edgar Deu , Yang Deng , Junpeng Xiao , Benjamin E. Turk , Jason R. Jessen , Stephen J. c ‡ *,† r Weiss , and Matthew Bogyo i p † t Department of Pathology, University School of Medicine, Stanford University, Stanford, CA 94305 USA ‡Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 USA §Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 USA N ||Department of Medicine/Division of Genetic Medicine, Vanderbilt University Medical Center, I H Nashville, TN 37232, USA - P A Abstract A u t Matrix metalloproteinases (MMPs) are zinc-endopeptidases that play roles in numerous h o pathophysiological processes and therefore are promising drug targets. However, the large size of r