structure determination of helical filaments by solid-state nmr spectroscopy.[10.1073pnas.1513119113].结构确定螺旋细丝的固态核磁共振光谱学。[10.1073 pn.pdfVIP

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structure determination of helical filaments by solid-state nmr spectroscopy.[10.1073pnas.1513119113].结构确定螺旋细丝的固态核磁共振光谱学。[10.1073 pn.pdf

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structure determination of helical filaments by solid-state nmr spectroscopy.[10.1073pnas.1513119113].结构确定螺旋细丝的固态核磁共振光谱学。[10.1073 pn

Structure determination of helical filaments by solid-state NMR spectroscopy a,1 b,1 a,c,2 a d e Lichun He , Benjamin Bardiaux , Mumdooh Ahmed , Johannes Spehr , Renate König , Heinrich Lünsdorf , Ulfert Randf g a,2,3 , Thorsten Lührs , and Christiane Ritter aLaboratory for Macromolecular Interactions, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; bUnité de Bioinformatique Structurale, CNRS UMR 3528, Institut Pasteur, 75015 Paris, France; cDepartment of Physics, Faculty of Science, Suez University, Suez, 43533, Egypt; dResearch Group “Host-Pathogen Interactions”, Paul-Ehrlich-Institut, 63225 Langen, Germany; eCentral Unit for Microscopy, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; f Immune Aging and Chronic Infection, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; and gSeNostic GmbH, 38124 Braunschweig, Germany Edited by G. Marius Clore, National Institutes of Health, Bethesda, MD, and approved December 2, 2015 (received for review July 3, 2015) The controlled formation of filamentous protein complexes plays a twist (around the helical axis) and the translational rise (along the crucial role in many biological systems and represents an emerging axis) between two subunits, the radius and the number of strands paradigm in signal transduction. The mitochondrial antiviral signal- defining the helical assembly (18). Without prior knowledge of ing protein (MAVS) is a central signal transduction hub in innate these parameters from complementary structural techniques, the immunity that is activated by a receptor-induced conversion into