凝血酶调节素加强人类循环前驱细胞于缺血肢之疗效（英文）精选.pptVIP

Thrombomodulin Enhances the Therapeutic Effects of Human Circulating Progenitor Cells in Ischemic Limb Overview of clinical studies evaluating different cell types Circulating Progenitor Cells Two different types of cultured MNC Thrombomodulin (TM) TM expression in human PBMNC cultured in different medium CFU in PBMNC respectively treated with TMD1, TMD23 and TMD123 (100 ng/ml) mRNA expression of early EPC treated with TMD23 (100 ng/ml) for 72h Analysis of Perfusion in Ischemic Limbs Thanks for your attention (Civin CL, et al. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol) Princess Takamatsu Symp. 1994;24:81-90.Links Sialomucin ligands for selectins: a new family of cell adhesion molecules.Lasky LA. Department of Immunobiology, Genentech, Inc., South San Francisco, CA 94080, USA. The specific migration of various leukocyte subsets to areas undergoing pathogenic attack is one of the cornerstones of the immune system. Assorted adhesion molecules, chemokines, non-protein signalling molecules, and their respective receptors are utilized during this process. The combinatorial matrix formed by this diversity of agents determines the cell type that migrates to a given class of inflammatory site. The selectins are a family of adhesion molecules that elicit the rolling response that initiates the inflammatory cascade. Selectins contain a type C lectin domain at their N-termini which recognizes sialylated, fucosylated carbohydrate ligands of the sialyl Lewis X (sLex) type. Recently, it has been demonstrated that these carbohydrate ligands are presented by a new class of adhesion molecules that have mucin-like structure and have been termed the sialomucin adhesion family. The function of this new family of adhesion molecules is to act as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidit