宫环止血片止血及镇痛作用的试验研究-JournalofIntegrativeMedicine.PDFVIP

中西医结 合学 报 2 004 年 3 月 第 2 卷 第 2 期 J Chin Integr Med , Mar 20 04 , V ol. 2 , No. 2 ·129 · 宫环 止 血 片 止 血 及 镇 痛 作 用 的实 验 研 究 付灵梅, 尤昭玲, 雷 磊, 文乐兮, 陈怀敏 ( 湖南中医学院中西医结合系, 湖南 长沙 4 10007) [ 摘要] 目的: 探讨宫环止血片对小 鼠的止血、镇痛作用, 为开发治疗铜宫内节育器所致子宫异常出血的新药提供实验依据 。 方法: 以氨基 己酸、三七粉作对照, 采用毛细玻管及小 鼠断尾法观 察宫环 止血片对小 鼠凝血、出血 时间的影响; 以阿司 匹林作 对照, 采用热板法及扭体法观察宫环止血片对小 鼠的镇痛 作用 。结果: 宫环 止血片 随剂量 的增加 而 明显缩短小 鼠凝血 时间, 各治疗组和蒸馏水组 比较都有显著性差异; 宫环止血片与蒸馏水组 比较, 各剂量组 都能明显缩短 出血时 间; 宫环止血 片各剂 量组均能延长小 鼠热板痛反应时间及减少小 鼠扭体次数 。结论: 药理实验证 明宫环止血片具有显著的止血、镇痛作用 。 [ 关键词] 宫环止血片; 凝血; 镇痛; 动物, 实验 [ 中图分类号] R96 5; R289 . 5 [ 文献标识码] A [ 文章编号] 1672 -1977 ( 2004 ) 02 - 012 9 - 03 H em o st a tic a n d a n algesic effect of Gon ghu an Z h ixu e T ab let on m ice FU Ling-Mei, YOU Zhao-Lin g, LEI Lei, WEN Le-Xi, CHEN Hu an -Min g ( Dep artmen t of In tegrated Traditional Chinese an d Western Medicine, Hu nan College of Traditional Ch inese Medicine, Ch an gsha, Hu- nan Province 4 10007 , Ch ina) AB STRACT Obj ectiv e: To explore the h emostatic and analgesic effect of Gonghuan Zhixu e Tablet ( GHZXT) on mice and to p ro- du ce exp erimental evid ence for exploiting new drug for end ometrorrh agia cau sed by Cu-intrauterine contraceptive d evice ( Cu-IUD) . M eth od s : Compared with 6-amin ocapr oic acid and notoginseng, th e effects of GHZXT on clotting and bleeding time of mice with cap il- lary meth od and severed tail were in vestigated; an d compar ed with aspirin , the analgesic effects of GHZXT on mice wer e in vestigated with hot plate and torsive body method. R esu lt s : The clottin g time of mice was r emarkably shortened with a rising of the d osage of GHZXT and the differ ence between each therap eutic group an d distilled water group was remark able . As compared with distilled water group , the bleeding time of each dosage gr oup of