[工学]高分子化学Supplement2008 Click.ppt

3、“链接”化学与生物共轭作用 铜(I)催化下叠氮化物-炔的偶极环加成反应的独特性为“链接”化学在活体内(in vivo)和活体外(in vitro)的生物共轭作用的应用提供了方便，并成功地应用于活的有机体和蛋白质、DNA 等的标记。 Finn 等成功的利用Cu(I)催化下形成1,2,3-三唑的反应，对完整的豇豆花叶病毒(CPMV)进行了标记。目前为止，这是对这个病毒衣壳最快和最可靠的标记方法。利用相似的方法，Link 等和Schultz 研究组分别对大肠杆菌(E. coli) 细胞和发面酵母(Saccharomyces cerevisiae)蛋白质了标记。 叠氮化物－炔的环加成对病毒、细胞和蛋白质的标记 4、链接化学在高分子化学中的应用 Sharpless 利用Cu(I)催化的叠氮化物-炔的环加成反应制备出高效的金属粘合剂材料 Fokin 相似的方法合成出了三唑树枝状大分子 L?ber 利用“链接”化学合成了含1,2,3-三唑环的功能性树脂，作为来合成多巴胺能芳香基脲化合物的载体 链接化学用于物质表面的功能化，如：通过对石英表面的衍生化把石英晶片连接起来，形成自组装单层膜(SAMs)来修饰完好(well-defined)电极的表面和黄金的表面 三臂不同聚合物的三星共聚物 Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 44, 5699–5707 (2006) 多孔聚合物色谱固定相 Analytical Chemistry, Vol. 78, No. 14, July 15, 2006 4969-4975 共轭聚合物 Chem. Commun., 2005, 4333–4335 树枝状肽 Chem. Commun., 2005, 4581–4583 星型聚己内酯和环糊精的超分子链接化学 Chem. Commun., 2006, 4010–4012 * * Prof. K. B. Sharpless, Prof. M. G. Finn Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 (USA) Fax: (+1) 858-784-7562 E-mail: sharples@scripps.edu Dr. H. C. Kolb Vice President of Chemistry Coelacanth Corporation East Windsor, NJ 08520 (USA) K. B. Sharpless M. G. Finn H. C. Kolb K. Barry Sharpless and his coworkers have discovered and developed many widely used catalytic oxidation processes, including the first general methods for stereoselective oxidation-the Sharpless reactions for asymmetric epoxidation, dihydroxylation, and aminohydroxylation of olefins. His mentors at Dartmouth College (BA in 1963), Stanford University (PhD in 1968 and postdoctoral research), and Harvard University (further postdoctoral research) were Prof. T. A. Spencer, Prof. E. E. van Tamelen, Prof. J. P. Collman, and Prof. K. Bloch, respectively. Before 1990, when he became W. M. Keck Professor of Chemistry at The Scripps Research Institute, Prof. Sharpless was a member of faculty at the Massachusetts Institute of Technology (1970-77, 1