抗生素作用的病理生理学Hunting intracellular bacteria with antibioticsPPT.pptVIP

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抗生素作用的病理生理学Hunting intracellular bacteria with antibioticsPPT.ppt

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抗生素作用的病理生理学Hunting intracellular bacteria with antibioticsPPT

Karmanshah, Iran, 24 May 2011 1st International and 12th Iranian Congress of Microbiology Intracellular SCVs and antibiotics … its hard to exceed 2 log drop… Perhaps due to membrane-detabilization effect … Domenech et al. Biochim Biophys Acta. 2009 1788:1832-1840 Baudoux et al. ICAAC 2009 [C1-1354] Nguyen et al., Antimicrobial Agents and Chemotherapy (2009) 53:1434–1442 Will this be successful ? * Hunting intracellular bacteria with antibiotics Paul M. Tulkens, MD, PhD Cellular and Molecular Pharmacology Unit Centre for Clinical PharmacyLouvain Drug Research Institute Catholic University of Louvain,Brussels, Belgium But before that, where are you from ? slides are available on www.facm.ucl.ac.be ? Lectures Belgium Brussels The medical campus of the Université catholique de Louvain The Cellular and Molecular Pharmacology Group Intracellular infection: bacterial strategies Carryn et al. Infect Dis Clin North Am. 2003;17:615-34. Intracellular infection and recurrence/relapses: the case of S. aureus (as an example) Intracellular infection and recurrence/relapses: the case of S. aureus (as an example) Phagocytic and non phagocytic cells in mastitis Brouillette et al., Microb. Pathog. (2003) 35:159-68 Settting up the model … Seral et al. Antimicrob. Agents Chemother. 2003 47:2283-2292 S. aureus virulence factors EbpS ClfA ClfB FnBPA FnBPB SpA IgG vWF elastin fibrinogen fibronectin Cna collagen staphyloxanthin Diseases-related toxins Hemolysins Hla Hlb Hlg tissues necrosis and inflammation Hld Coa Degradatives enzymes S. aureus Eukaryotic cell internalization α5β1integrin nucleases proteases lipases collagenase hyaluronidase prothrombin KatA H2O2 H2O Adhesion – Invasion (early steps of infection) Protection vs. host defenses Colonization - Degradation - Nutrition (late steps of infection) PVL SEs ETs TSST-1 Toxic shock syndrome Food poisoning Skin infections necrotizing pneumonia Scald skin syndrome impetigo Olivier et al., Role of virulence factors in S.