高同型半胱氨酸血症与脑卒中、TIA的相关性分析.docVIP

精品论文 参考文献 高同型半胱氨酸血症与脑卒中、TIA的相关性分析 周艳霞 　　【摘 要】　目的　探讨高同型半胱氨酸（HCY）血症与脑卒中、TIA的关系。方法　为横断面调查研究，采用知情自愿原则，以年龄大于等于 40岁的人群作为研究对象，采取整群抽样方法，选取398例TIA患者(TIA组)、216例脑卒中患者(脑卒中组)为病例组，选取2038例正常人群作为对照组，采用酶联免疫吸附法检测各组的血清HCY水平，比较各组的HCY水平、高HCY的比例、Ｈ型高血压比例，并分析HCY与年龄、性别的相关性。分别以脑卒中、TIA为自变量，性别、年龄、高HCY、H型高血压为因变量，进行多因素logistic回归分析。结果　(１)脑卒中组的HCY水平均高于正常人群组，p＜0.05；(２)脑卒中组的H型高血压比例高于正常人组；(３) 脑卒中组、正常人组的HCY水平随着年龄的增长而升高，而且有统计学差异,p＜0.05；(４) logistic回归分析显示：男性、高龄、高血压都是脑卒中的独立危险因素，高龄，高血压都是TIA的独立危险因素。结论 高同型半胱氨酸血症及H型高血压与脑卒中密观相关。 　　【关键词】 高同型半胱氨酸血症； 脑血管病； H型高血压 　　 　　The Associative Analysis of Hyperhomocysteinemia and stroke、transient ischemic attack Zhou Yanxia，Han Man Fu，Tang Xiang, Long Xia（Department of Neurology，Shenzhen Municipal Second Peoplersquo;s Hospital，Guangdong Province，Shenzhen 518035，China） 　　 　　【Abstract】 Objective　To investingate the relationship between the level of plasma homocysteine and stroke、transient ischemic attack in patients.Methods The serum homocysteine(HCY)levels of 2038 healthy volunteers、398 patients with transient ischemic attack and 216 patients with cerebral hemorrhage of were measured, comparing the serum homocysteine(HCY)levels and the proportion of hyperhomocysteinemia and H-type hypertension were compared，and the risk factors were analyzed. Results (1)The serum HCY levels in stroke was higher than those in control group(plt;0．05)．(2) The proportion of hyperhomocysteinemia in stroke was higher than those in control group(plt;0．05).(3) With the age increasing, The serum homocysteine(HCY)levels in strokes and normal people were increased. (3) Logistic regression analysis showed that hypertension、age and man were the more sensitive risk factors of stroke，age and hypertension were the more sensitive risk factors of transient ischemic attack. Conclusion The relationship between the level of plasma homocysteine and stroke、transient ischemic attack were important. 　　高同型半胱氨酸血症(Hyperhomocysteinemia ,HHCY) 目前被认为是心脑血管事件的独立危险因素之一。既往对于HHCY的临床研究主要针对住院患者及体检人群的对照分析，较少对社区