趋化信号接枝的掺镁羟基磷灰石促进间充质干细胞归巢精选.pdfVIP

Engineering 3 (2017) 55–59 Contents lists available at ScienceDirect Engineering journal homepage: /locate/eng Research Tissue Engineering—Article Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite a, a a a b Alessandro Pistone *, Daniela Iannazzo , Claudia Espro , Signorino Galvagno , Anna Tampieri , b b b Monica Montesi , Silvia Panseri , Monica Sandri a Department of Engineering, University of Messina, Messina 98166, Italy b Institute of Science and Technology for Ceramics, National Research Council of Italy, Faenza 48018, Italy a r t i c l e i n f o a b s t r a c t Article history: Stem cell homing, namely the recruitment of mesenchymal stem cells (MSCs) to injured tissues, is Received 14 October 2016 highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic Revised 13 January 2017 peptide sequences on magnesium-doped (Mg-doped) hydroxyapatite (HA) may regulate the homing of Accepted 16 January 2017 MSCs, and thus induce cell migration to a specific site, we covalently functionalized MgHA disks with Available online 20 February 2017 two chemotactic/haptotactic factors: either the fibronectin fragment III -C human (FF III -C), or the pep-