微囊藻毒素引起鲫低血压和低血容量休克精选.pdfVIP

Toxicon 53 (2009) 638–644 Contents lists available at ScienceDirect Toxicon journal homepage: www.els /locate/toxicon Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus) Dapeng Li a, b, Ping Xie a, b, *, Xuezhen Zhang a, Yanyan Zhao a a Key Laboratory of Freshwater Biodiversity Conservation and Utilization of Ministry of Agriculture, College of Fishery, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China b Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People’s Republic of China a r t i c l e i n f o a b s t r a c t Article history: Circulatory responses of crucian carp injected intraperitoneally with extracted micro- Received 15 October 2008 cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mg MC kg1 body Received in revised form 23 January 2009 mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red Accepted 26 January 2009 blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, Available online 4 February 2009 and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal Keywords: