腹腔镜胆囊切除术后胆管直径变化与免疫状态的相关性研究.docVIP

精品论文 参考文献 腹腔镜胆囊切除术后胆管直径变化与免疫状态的相关性研究 司英辉１　宫梦雪１　苗永锋１　李志峰２　赵军苍３ １．河北省邯郸市魏县人民医院外三科　河北　邯郸　０５６８００;２．邯郸市第一医院普外科　河北　邯郸　０５６８００;３．邯郸市中心医院急诊外科　河北　邯郸　０５６８００ 　　【摘要】　目的　探讨与分析腹腔镜胆囊切除术后胆管直径变化与免疫状态.方法　来我院进行腹腔镜胆囊切除术的患者为实验组,正常人群为对照组,比较两组手术前、后胆总管直径的变化,比较两组手术前、后的血清IFNgamma;、TNFalpha;、IL－４和IL－１０水平以及TH１和TH２的变化.结果　经统计分析,实验组术前和术后３个月的胆管直径与对照组相比的差异具有显著的统计学意义,P＜０．０５.术后３个月,实验组的TNFalpha;、IL－４、IL－１０与对照组的TNFalpha;、IL－４、IL－１０ 的差异具有统计学意义,P＜０．０５.实验组的IL－１０与对照组的IL－１０的差异具有显著的统计学意义,P＜０．０５.术后３个月,实验组的TH１和TH１/TH２的差异具有显著的统计学意义,P＜０．０５;术后６个月,实验组的TH１和TH１/TH２的差异具有显著的统计学意义,P＜０．０５.结论　腹腔镜胆囊切除术后,胆管直径发生一定程度的扩张,与机体的免疫状态密切相关,为临床的治疗提供一定的价值和意义. 【关键词】　腹腔镜胆囊切除术;　胆管直径;　免疫状态Researchofbileductdiameterchangeandimmunestateafterlaparoscopiccholecystectomy【Abstract】　ObjectiveToexploreandanalyzethebileductdiameterchangeandimmunestateafterlaparoscopiccholecystectomy．MethodsPatientsinourhospitalwithlaparoscopiccholecystectomyweresetasexperimentalgroup,normalpeopleascontrolgroup．Comparethebileductdiameterchange,IFNgamma;,TNFalpha;,IL－４,IL－１０andTH１/TH２betweentwogroupsbeforeandaftersurgery．ResultsTherewerestatisticallysignificantdifferencesinductdiameterbeＧtweentwogroupspreoperativeandpostoperative３months,P＜０．０５．After３months,therewerestatisticallysignificantdifferencesinTNFalpha;,IL－４,IL－１０beＧtweentwogroups,P＜０．０５．After６months,therewerestatisticallysignificantdifferencesinIL－１０betweentwogroups,P＜０．０５．After３months,therewerestatisticallysignificantdifferencesinTH１/TH２betweentwogroups,P＜０．０５．After６months,therewerestatisticallysignificantdifferencesinTH１/TH２beＧtweentwogroups,P＜０．０５．ConclusionAfterlaparoscopiccholecystectomy,therewerecertaindegreesofexpansioninbileductdiameter,whichwerecloselyasＧsociat【eKdeywiwthortdhse】body＇simmunestatus．Alltheseresultsprovidedcertainvalueandsignificanceforclinicaltreatment． 　Laparoscopiccholecystectomy;　Bileductdiameter;Immunestatus 【中图分类号】R６５７．４ 【文献标识码】B 　　【文章编号】１００８－６３１５(２０１５)１０－０３１３－０２　　 　　胆囊切除术作为治疗胆囊疾病的主要手段,是胆道外科常用的手术方式. 传统的开腹胆囊切除术虽然能在一定程度上缓解患者的病痛,达到治疗疾病的目的.但这种手术方式创伤较大,伤口愈合较慢,术后容易出现不同的并发症,会导致患者出现不同程