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Selective Inhibition of by Analogue Thiazolidine-4-Carboxylic…
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 1975, P. 25-31 Vol. 7, No. 2 Copyright 0 1975 American Society for Microbiology Printed in U.S.A. Selective Inhibition of Growth by the Proline Analogue Thiazolidine-4-Carboxylic Acid and Its Probable Mode of Action in Saccharomyces cerevisiae JAMES R. PATERNITI, JR.,* DAVID WILKIE, AND NORMAN R. EATON Department of Biology, Brooklyn College, Brooklyn, New York 11210,* and the Department of Botany and Microbiology, University College, London, England Received for publication 27 August 1974 D Cells of Saccharomyces cerevisiae showed differential growth inhibition when o w cultured on various carbon sources in the presence of the proline analogue n l thiazolidine-4-carboxylic acid (TZ). On 0.5% yeast extract, 2% glucose and TZ o a d (10 mg/ml) medium, growth lags from 8 to 10 h were observed, after which cells recovered and growth proceeded normally. Growth was totally inhibited on a e
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