青脆枝化学成分及其活性研究进展.PDFVIP

2016,45(4): 379 ～385. Subtropical Plant Science 青脆枝化学成分及其活性研究进展 沈瑞池，吴美芳，何恩铭，陈德林，王 杰，何建章，周 爽 (福建省亚热带植物研究所，福建省亚热带植物生理生化重点实验室，福建 厦门 361006) 摘 要：喜树碱是已发现的唯一专门通过抑制拓扑异构酶Ⅰ发挥细胞毒性的天然植物成分，具有广谱抗肿瘤活 性。青脆枝 Nothapodytes nimmoniana 含有多种喜树碱类化合物及其他活性成分，其中喜树碱、9- 甲氧基喜树碱 和羟基喜树碱含量最为丰富，是重要的药用植物。文中综述青脆枝主要化学成分、生物活性及其提取方法，并 对青脆枝的应用前景作展望。 关键词：青脆枝；喜树碱；化学成分；生物活性；提取 Doi: 10.3969/j.issn.1009-7791.2016.04.017 中图分类号：Q946.8 文献标识码：A 文章编号：1009-7791(2016)04-0379-07 Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana SHEN Rui-chi, WU Mei-fang, HE En-ming, CHEN De-lin, WANG Jie, HE Jian-zhang, ZHOU Shuang (Fujian Institute of Subtropical Botany, Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Xiamen 361006, Fujian China) Abstract: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which is only one specially inhibiting the DNA enzyme topoisomerase I (topo I), showes remarkable anticancer activity. There are many CPTs and other active ingredients in Nothapodytes nimmoniana , the contents of CPT, 9-methoxycamptothecin and hydroxycamptothecin in Nothapodytes nimmoniana are most abundant. N. nimmoniana have become an important medicinal plant. In this paper, the chemical constituents, their biological activity and extraction methods of N. nimmoniana were summarized. In addition, the development and utilization prospect of N. nimmoniana were introduced. Key words: Nothapodytes nimmoniana ; camptothecin; chemical constituents; biological activity; extraction [1] 临床应用药物较多直接或间接来源于天然活性化合物 。青脆枝