检测肱动脉血流介导的血管舒张功能在预测妊娠期高血压疾病中的价值.docVIP

精品论文 参考文献 检测肱动脉血流介导的血管舒张功能在预测妊娠期高血压疾病中的价值 周金凤　王常永 （广州开发区医院　广东　广州　5 10 73 0;武汉大学人民医院重症医学科　湖北　武汉　43 00 00） 【摘要】目的：探讨肱动脉血流介导的血管舒张功能在预测妊娠期高血压疾病中的价值。方法：我们选取81名孕周小于18周的孕妇作为研究对象，在妊娠期间监测两次肱动脉血流介导的血管舒张功能(FMD)，比较妊娠高血压疾病组（高血压组）和正常组FMD。结果：正常组FMD1平均值为（20.9plusmn;12.70）%，高血压组FMD1平均值为(6.7plusmn;3.2)%，差异有显著性( Plt; 0. 01)，正常组FMD2平均值为（25plusmn;11）%，高血压组FMD2平均值(6plusmn;4.3)%，差异也有显著性( P lt; 0. 01)。测量FMD1时高血压组平均孕龄为（19.65plusmn;1.42）周，测量FMD2时高血压组孕妇平均孕龄为（29.7plusmn;1.24）周，测量FMD1与罹患妊娠期高血压疾病的平均时间间隔为（13.8plusmn;2.9）周，测量FMD2和罹患妊娠期高血压疾病的平均时间间隔为（3.8plusmn;3.2）周。结论：孕18　21周检测FMD是在早期预测妊娠高血压疾病中有一定价值。 【关键词】妊娠；肱动脉血流介导的血管舒张功能；高血压 The value of detecting flow mediated dilatation of brachial artery in women in predicting hypertension disorder complicating pregnancy 【Abstract】Objective:To evaluate the flow mediated vasodilatation of brachial artery in women at risk of development of pregnancy inducedhypertension.Methods:We enrolled 81 pregnant women at less than 18 weeks of gestation.Flow mediated vasodilatation(FMD) was assessed twice inpregnancy.The FMD at different gestations were compared between subjects，who developed PIH(hypertension groups)and those who remainednormotensive(normal groups).Results:Mean FMD1 of normotensives wa（s 20.9plusmn;12.7 0）% whereas that of hypertensives was (6.7plusmn;3.2)% showing astatistically significant difference(Plt;0.01).Mean FMD2 of normotensives wa（s 25plusmn;11）% whereas that of hypertensives was (6plusmn;4.3)% showing a statistically significant difference other( Plt; 0.01).The mean gestational age at measurement of FMD1 in those with PIH wa（s 19.65plusmn;1.42）weeks and thatof FMD2wa（s 29.7plusmn;1.24）weeks.The mean interval between measurement of FMD1 and development of PIH wa（s 13.8plusmn;2.9）weeks，The mean interval between measurement of FMD2 and development of PIH wa（s 3.8plusmn;3.2）weeks.Conclusion:Flow mediated vasodilatation of brachial arterywhen measured between 18　21 weeks is found to be a useful early predictor of pregnancy induced hypertension.Keyword