检测不孕不育患者血清中AsAb和ACA的临床意义.docVIP

精品论文 参考文献 检测不孕不育患者血清中AsAb和ACA的临床意义 （镇江市第二人民医院 江苏 镇江 212002） 　　【摘要】 目的：探讨对不孕不育男女检测抗精子抗体(AsAb)和抗心磷脂抗体(ACA)的临床意义。方法：收集2014年7月～2015年6月在我院诊断诊断为不孕不育的102对夫妇为观察组，随机选取同期进行健康检查的90对正常生育夫妇为对照组。对比分析两组研究对象AsAb 和ACA的阳性率。结果：对照组90例男性AsAb阳性数2例(2.2%)，ACA阳性6例(6.7%)，对照组90例女性AsAb阳性数1例(1.1%)，ACA阳性2例(2.2%)，观察组102例男性AsAb阳性35例(34.3%)，ACA阳性12例(11.8%)观察组102例女性AsAb阳性28例(27.5%)，ACA阳性27例(26.5%)。与对照组比，观察组男性与女性的AsAb阳性例数较多，女性的ACA阳性例数较多(Plt;0.05)。对照组男性与女性AsAb阳性均为IgG型，不孕男性与女性的IgM型 AsAb阳性率明显高于IgG型、IgA型和IgG+IgM(Plt;0.05)。对照组男性与女性ACA阳性均为IgG型，不孕男性与女性的IgG型分明显高于IgM和IgA(Plt;0.05)。结论：AsAb 和ACA是造成患者不孕不育的重要因素，AsAb-IgM抗体类型表达相对较多，是影响不孕不育重要的免疫性抗体，对不孕不育的诊断有重要的临床意义。 　　【关键词】 AsAb；ACA；不孕不育 　　【中图分类号】R446.62 【文献标识码】A 【文章编号】2095-1752（2016）29-0165-02 　　The Clinical significance of detection of AsAb and ACA in infertility Zeng Guangjian, Lu Guangren，Liu Zhuomin, Xinhua community health service center in Huadu District of Guangzhou City （Xinhua Hospital ）510800,China 　　【Abstract】Objective To investigate the clinical significance of detection of antisperm antibodies (AsAb) and anticardiolipin antibody (ACA) in male and female infertility. Methods From July 2014 -2015 year in June, 102 infertility couples in our hospital were selected in our study. 90 healthy couples were collected as the control group. AsAb and ACA in 2 groups, and sperm general examination of all male cases were determined and compared. Results In 90 cases of control group, 2 cases male AsAb and 6 cases male ACA were determined with the positive rates of 2.2% and 6.7%, respectively. 1 cases male AsAb and 2 cases male ACA were determined with the positive rates of 1.1% and 2.2%, respectively. In 102 cases of observation group, 35 cases male AsAb and 12 cases male ACA were determined with the positive rates of 34.3% and 11.8%, respectively. 28 cases female AsAb and 27 cases female ACA were determined with the positive rates of 27.5% and 26.5%, respectively. Compared with control, the male and female cases of AsAb an