探讨腹腔灌注化疗加静脉化疗与静脉化疗治疗中晚期卵巢癌临床效果.docVIP

精品论文 参考文献 探讨腹腔灌注化疗加静脉化疗与静脉化疗治疗中晚期卵巢癌临床效果 望奎县人民医院 152100 【摘 要】目的 对比分析顺铂腹腔灌注联合多西紫杉醇加顺铂静脉化疗双途径治疗与顺铂联合多西紫杉醇单纯静脉化疗治疗晚期卵巢癌的临床疗效、不良反应。方法 此次研究的对象是选择中晚期卵巢癌患者42例，将其临床资料进行回顾性分析，并随机分为治疗组A组：顺铂腹腔灌注联合多西紫杉醇加顺铂静脉化疗双途径治疗）20例，对照组B组：顺铂联合多西紫杉醇单纯静脉化疗22例。结果 治疗组有效率82.14%（23/28），对照组有效率70.37%（19/27），两组比较，差异有显著性（Plt;0.05）。全身毒性反应主要为消化道反应、肾毒性、血液学毒性和神经毒性，全身毒性反应治疗组较对照组略低；而局部毒性主要有腹痛、化学性腹膜炎和腹腔粘连，局部毒性反应治疗组较对照组略高。组间比较差异无显著性（Pgt;0.05）。结论 治疗组较对照组治疗晚期卵巢癌疗效更高，毒性反应可以耐受，腹腔化疗应用于中晚期卵巢癌是一种安全而有效的的治疗模式，患者有较好的耐受性。 【关键词】卵巢癌；腹腔灌注化疗；静脉化疗；多西紫杉醇；顺铂 Abstract： Objective To compare the clinical efficacy of cisplatin combined with docetaxel plus cisplatin and intravenous chemotherapy with cisplatin plus docetaxel treatment double way intravenous chemotherapy in the treatment of advanced ovarian cancer adverse reaction.The object of this research method is to select the advanced ovarian cancer patients in 42 cases，the clinical data were retrospectively analyzed，and randomly divided into treatment group A group： intraperitoneal cisplatin combined with docetaxel plus cisplatin chemotherapy treatment in 20 cases，double way）group B： cisplatin combined with docetaxel intravenous chemotherapy in 22 cases.Results the effective rate of the treatment group was 82.14%（23/28），the control group was 70.37%（19/27），the difference was significant（Plt;0.05），the difference was significant（）.All the main toxicities were gastrointestinal reactions，renal toxicity，hematologic toxicity and neurotoxicity，systemic toxicity in treatment group than in the control group is slightly lower; and local toxicity mainly include abdominal pain，chemical peritonitis and peritoneal adhesion，local toxicity slightly higher in treatment group than in the control group.There were no significant difference between them（Pgt;0.05）.Conclusion the curative effect of the treatment group than the control group in the treatment of advanced ovarian cancer higher toxicity of intraperitoneal chemotherapy in advanced ovarian cancer is a safe and ef