Mitochondrial homeostasis：The interplay between mitophagy and mitochondrial biogenesis英文电子书.pdf

EXG-09344; No of Pages 7 Experimental Gerontology xxx (2014) xxx–xxx Contents lists available at ScienceDirect Experimental Gerontology j o ur nal homepage: www.el sevier. com/ locate/ expgero Review Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis Konstantinos Palikaras, Nektarios Tavernarakis ⁎ Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece a r t i c l e i n f o a b s t r a c t Article history: Mitochondria are highly dynamic organelles and their proper function is crucial for the maintenance of cellular Received 7 November 2013 homeostasis. Mitochondrial biogenesis and mitophagy are two pathways that regulate mitochondrial content Received in revised form 15 January 2014 and metabolism preserving homeostasis. The tight regulation between these opposing processes is essential Accepted 20 January 2014 for cellular adaptation in response to cellular metabolic state, stress and other intracellular or environmental Available online xxxx signals. Interestingly, imbalance between mitochondrial proliferation and degradation process results in progres- Keywords: sive development of numerous pathologic conditions. Here we review recent studies that highlight the intricate Ageing interplay between mitochondrial biogenesis and mitophagy, mainly focusing on the molecular mechanis