有哪些信誉好的足球投注网站- 1、本文档共14页，可阅读全部内容。
- 2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
Bandyopadhyay et al. Silence 2010, 1:6
/content/1/1/6
R E S E A R C H Open Access
Research
Development of the human cancer microRNA
network
1 1 2 3,4
Sanghamitra Bandyopadhyay* , Ramkrishna Mitra , Ujjwal Maulik and Michael Q Zhang
Abstract
Background: MicroRNAs are a class of small noncoding RNAs that are abnormally expressed in different cancer cells.
Molecular signature of miRNAs in different malignancies suggests that these are not only actively involved in the
pathogenesis of human cancer but also have a significant role in patients survival. The differential expression patterns
of specific miRNAs in a specific cancer tissue type have been reported in hundreds of research articles. However limited
attempt has been made to collate this multitude of information and obtain a global perspective of miRNA
dysregulation in multiple cancer types.
Results: In this article a cancer-miRNA network is developed by mining the literature of experimentally verified cancer-
miRNA relationships. This network throws up several new and interesting biological insights which were not evident in
individual experiments, but become evident when studied in the global perspective. From the network a number of
cancer-miRNA modules have been identified based on a computational approach to mine associations between cancer
types and miRNAs. The modules that are generated based on these association are found to have a number of
common predicted target onco/tumor suppressor genes. This suggests a combinatorial effect of the module
associated miRNAs on target gene regulation in selective cancer tissues or cell lines. Moreover, neighboring miRNAs
(group of miRNAs that are located within 50 kb of genomic location) of these modules s
您可能关注的文档
- Johnny Rabb The Official Freehand Technique英文电子书.pdf
- Multiwavelength Fluorescence Detection For Dna Sequencing Using Capillary Electrophoresis英文电子书.pdf
- Microstructures and sliding wear resistances of 0.2arbon steel coatings deposited by HVOF and PTWA thermal spray processes英文电子书.pdf
- Maternal allergic disease does not affect the phenotype of T and B cells or the immune response to allergens in neonates英文电子书.pdf
- The anti diabetic effect of anthocyanins in streptozotocin induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis英文电子书.pdf
- Postoperative Pain Management Good Clinical Practice (Esra) Ww英文电子书.pdf
- Grebe type chondrodysplasia a novel missense mutation in a conserved cysteine of the growth differentiation factor 5英文电子书.pdf
- GRADIENTES DE CAMPO MAGNTICO EN EXPERIMENTOS DE RMN MRI NMR spectroscopy proton nuclear magnetic resonance imaging 2006 by英文电子书.pdf
- Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients英文电子书.pdf
- Global Convergence Of The Recursive Kernel Regression Estimates With Applications In Classification And Nonlinear System Estimation英文电子书.pdf
文档评论（0）